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首页> 外文期刊>Journal of the mechanical behavior of biomedical materials >Sterculia crosslinked PVA and PVA-poly(AAm) hydrogel wound dressings for slow drug delivery: mechanical, mucoadhesive, biocompatible and permeability properties.
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Sterculia crosslinked PVA and PVA-poly(AAm) hydrogel wound dressings for slow drug delivery: mechanical, mucoadhesive, biocompatible and permeability properties.

机译：Sterculia交联的PVA和PVA-poly（AAm）水凝胶伤口敷料用于缓慢的药物输送：机械，粘膜粘附，生物相容性和渗透性。

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摘要

The present study deals with the synthesis and characterization of sterculia crosslinked PVA and PVA-AAm hydrogel wound dressings. The hydrogels have been characterized by SEMs, FTIR, TGA and swelling studies. This article also discusses comparison of swelling, drug release and biomedical properties such as blood compatibility, antimicrobial activity, mucoadhesion, tensile strength, burst strength, water vapour permeability, oxygen diffusion and microbial penetration of both hydrogel wound dressings. These polymeric films have absorbed 4.80 ± 0.15 and 6.32 ± 0.15 gram/g of gel of simulated wound fluid respectively and swelling occurred through Case II diffusion mechanism. The release of antibiotic drugs occurred through non-Fickian and Case II diffusion mechanisms, respectively. These polymeric films have been observed to be permeable for oxygen and water vapour but have shown impermeability to the micro-organism. Sterculia-PVA hydrogel wound dressing has shown more blood compatibility as compared to the other film. All these results indicate that these hydrogel films may be used as wound dressings for the slow release of antibiotic drug to the wound.
机译：本研究涉及立体交联的PVA和PVA-AAm水凝胶伤口敷料的合成和表征。通过SEM，FTIR，TGA和溶胀研究对水凝胶进行了表征。本文还讨论了两种水凝胶伤口敷料的溶胀，药物释放和生物医学特性（例如血液相容性，抗菌活性，粘膜粘附，抗张强度，破裂强度，水蒸气渗透性，氧扩散和微生物渗透）的比较。这些聚合物薄膜分别吸收了4.80±0.15克/克和6.32±0.15克/克的模拟伤口液凝胶，并且通过案例II扩散机制发生了溶胀。抗生素药物的释放分别通过非Fickian和Case II扩散机制发生。已经观察到这些聚合物膜对于氧气和水蒸气是可渗透的，但是已经显示出对微生物的不可渗透性。与其他薄膜相比，Sterculia-PVA水凝胶伤口敷料显示出更多的血液相容性。所有这些结果表明，这些水凝胶膜可以用作伤口敷料，以将抗生素药物缓慢释放至伤口。

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