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首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Resting tremor only: a variant of Parkinson's disease or of essential tremor.
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Resting tremor only: a variant of Parkinson's disease or of essential tremor.

机译：仅静息性震颤：帕金森氏病或原发性震颤的一种变体。

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Resting tremor is one of the characteristic features of Parkinson's disease. However, there are a number of patients who typically have resting tremor alone for at least 5 years without development of other parkinsonian signs or symptoms. The etiology of an isolated resting tremor is still obscure. Recently, positron emission tomography was used to study these patients with isolated resting tremor, and demonstrated a markedly decreased striatal uptake of fluoro-dopa to the range of Parkinson's disease. These findings suggested the existence of a separate subtype, namely, tremulous Parkinson's disease with a manifestation of resting tremor alone. In order to confirm the existence of this subgroup of tremulous Parkinson's disease and further investigate its morphological changes and the usefulness of magnetic resonance imaging, we collected 5 patients who typically have resting tremor for at least 8 years in the absence of other features of Parkinson's disease. MRI was performed and the results of the images showed typical findings of Parkinson's disease with smudging or decreased distance between substantia nigra and red nucleus. Quantitative analysis also demonstrated a significant decrease of the above-noted distance when the resting tremor group was compared to the essential tremor group. Therefore, patients with an isolated resting tremor can have morphological abnormalities in addition to functional disturbances shown by positron emission tomography. To our knowledge, this is the first paper to report that resting tremor is a variant of Parkinson's disease rather than essential tremor, by using a double-blind method, with magnetic resonance imaging to support.
机译：静息性震颤是帕金森氏病的特征之一。但是，有许多患者通常仅在至少5年内静息震颤而没有其他帕金森氏体征或症状的发展。孤立的静息性震颤的病因仍不清楚。最近，正电子发射断层扫描技术被用于研究这些患有孤立性静息震颤的患者，并证实纹状体对氟多巴的摄取显着降低至帕金森氏病的范围。这些发现提示存在单独的亚型，即仅表现为静息性震颤的震颤性帕金森氏病。为了确认该亚型帕金森氏病的存在并进一步研究其形态变化和磁共振成像的实用性，我们收集了5例在没有其他帕金森氏病特征的情况下通常至少有8年静息震颤的患者。进行了MRI检查，图像结果显示了典型的帕金森氏病，伴有黑质和红色核之间的污迹或距离缩短。定量分析还表明，将静息震颤组与基本震颤组进行比较时，上述距离显着减少。因此，患有孤立性静息性震颤的患者除了正电子发射断层扫描所显示的功能障碍外，还会出现形态异常。据我们所知，这是第一篇报道静息性震颤是帕金森氏病的变种，而非原发性震颤的第一篇论文。

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