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首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study.
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Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study.

机译：血管性认知障碍中的疾病进展：研究血管性认知障碍联合会（CIVIC）队列研究的认知，功能和行为结果。

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BACKGROUND AND PURPOSE: Empirical studies to clarify the outcomes in Vascular Cognitive Impairment (VCI) are needed. We compared cognitive, functional, and behavioural outcomes in patients with VCI to patients with no cognitive impairment (NCI), and Alzheimer's disease (AD). METHODS: Secondary analysis of the Consortium to Investigate Vascular Impairment of Cognition (CIVIC), a multi-centre Canadian memory clinic 30-month cohort study. RESULTS: Of 1347 patients, 938 were eligible for follow-up, of whom 239 (24.5%) were lost and 29 (3%) had died. Of the remaining 697 patients, 125 had NCI, 229 had VCI, and 343 had AD at baseline. Compared to people with NCI, of whom 20-40% showed progression based on cognitive and functional measures, those with VCI were more likely to progress (50-65%), as were people with AD (50-80%) (p<0.01). More people with VCI showed progression of affective symptoms (30%) than those with NCI (12%) or AD (15% p<0.01). Progression of impaired judgment (rated clinically) in VCI (15%) was similar to AD (11%) but more common than in NCI (4%, p<0.01). CONCLUSIONS: Most people with VCI show readily detectable progression by 30 months. Depressive symptoms were more common and more progressive in VCI than in Alzheimer's disease, whereas clinical evidence of progressive executive dysfunction was common in both AD and VCI.
机译：背景与目的：需要进行实验研究以澄清血管性认知障碍（VCI）的结果。我们将VCI患者与无认知障碍（NCI）和阿尔茨海默氏病（AD）的患者的认知，功能和行为结局进行了比较。方法：对多中心加拿大记忆诊所为期30个月的队列研究进行的研究，以调查认知血管损害联盟（CIVIC）。结果：在1347例患者中，有938例符合随访条件，其中239例（24.5％）丢失，29例（3％）死亡。其余697例患者中，基线时有NCI 125例，VCI 229例，AD 343例。与NCI患者相比，其中20-40％的患者基于认知和功能指标显示进展，而VCI患者与AD患者（50-80％）的进展可能性更高（50-65％）（p < 0.01）。与NCI（12％）或AD（15％p <0.01）相比，VCI表现出情感症状进展的比例更高（30％）。 VCI（15％）的判断障碍（临床评价）进展与AD（11％）相似，但比NCI（4％，p <0.01）更常见。结论：大多数VCI患者在30个月内显示出可检测到的进展。与阿尔茨海默氏病相比，VCI中的抑郁症状更为常见，并且进行性更强，而AD和VCI均具有进行性执行功能障碍的临床证据。

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