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首页> 外文期刊>Journal of the Society for Gynecologic Investigation >Steroid-modulated proliferation of human endometrial carcinoma cell lines: any role for insulin-like growth factor signaling?
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Steroid-modulated proliferation of human endometrial carcinoma cell lines: any role for insulin-like growth factor signaling?

机译：类固醇调节人子宫内膜癌细胞的增殖：胰岛素样生长因子信号传导的任何作用？

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OBJECTIVES: Estrogen-stimulated proliferation of the normal and malignant human endometrium is balanced by the differentiating properties of progesterone. This study evaluated the role of insulin-like growth factor (IGF) signaling in steroid-induced modulation of endometrial cancer cell proliferation. METHODS: We used the human endometrial, estrogen-responsive ECC-1 and progesterone-responsive PRAB-36 cell lines. Proliferation studies with IGFs in combination with either estrogen or progesterone were conducted. Furthermore, the mRNA and protein expression of insulin-like growth factor-binding proteins (IGFBPs) was evaluated. RESULTS: Using the ECC-1 cell line, we observed that estrogen-induced proliferation is modulated via the IGF-receptor signaling pathway, and that IGF-1-induced stimulation of proliferation does not influence estrogen receptor signaling. Furthermore, expression of the main modulators of IGF action, the IGFBPs, was found to be regulated by estrogen and progesterone in both cell lines. IGFBP-4 was up-regulated by estrogen in the ECC-1 cell line, and IGFBP-3 and IGFBP-6 were down-regulated by progesterone in the PRAB-36 cell line. CONCLUSION: Estrogen-induced stimulation of proliferation of ECC-1 endometrial cancer cells is partly achieved via IGF signaling. Furthermore, the IGFBPs are regulated by estrogens as well as progestagens and could potentially play a role in the modulation of endometrial cancer cell proliferation.
机译：目的：雌激素刺激的正常人和恶性人子宫内膜的增殖通过孕激素的不同特性得到平衡。这项研究评估胰岛素样生长因子（IGF）信号在类固醇诱导的子宫内膜癌细胞增殖调节中的作用。方法：我们使用了人类子宫内膜，雌激素反应性ECC-1和孕激素反应性PRAB-36细胞系。进行了IGFs与雌激素或孕激素联合使用的增殖研究。此外，评估了胰岛素样生长因子结合蛋白（IGFBPs）的mRNA和蛋白表达。结果：使用ECC-1细胞系，我们观察到雌激素诱导的增殖是通过IGF-受体信号传导途径调节的，而IGF-1诱导的增殖刺激并不影响雌激素受体的信号传导。此外，发现两种细胞系中IGF作用的主要调节剂IGFBPs的表达均受雌激素和孕激素的调节。雌激素在ECC-1细胞系中上调IGFBP-4，而孕酮在PRAB-36细胞系中下调IGFBP-3和IGFBP-6。结论：雌激素诱导的ECC-1子宫内膜癌细胞增殖的刺激部分是通过IGF信号传导实现的。此外，IGFBP受雌激素和孕激素调节，并可能在子宫内膜癌细胞增殖的调节中发挥作用。

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