• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Society for Gynecologic Investigation >Peripheral polymorphonuclear leukocyte priming contributes to oxidative stress in early pregnancy.
【24h】

Peripheral polymorphonuclear leukocyte priming contributes to oxidative stress in early pregnancy.

机译：外周多形核白细胞启动促成妊娠早期的氧化应激。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The cause of elevated blood leukocyte count in pregnancy is unknown. We hypothesized that priming of peripheral polymorphonuclear leukocytes (PMNL) caused this elevation. METHODS: Eleven women in the first trimester of pregnancy were included in this prospective study. Peripheral venous blood was drawn twice from each woman, before and after a medical abortion (pregnant and nonpregnant, respectively). Complete blood cell count, plasma alkaline phosphatase (ALP), and rate of superoxide release from separated phobrol 12-myristate-13-acetate (PMA)-stimulated PMNL were determined. RESULTS: The PMNL count in early pregnancy was significantly higher, with a significant increase in the PMNL rate of superoxide release compared to the nonpregnant state. A linear correlation between the rates of superoxide release and PMNL counts before and during pregnancy was found. ALP levels were significantly elevated in early pregnancy. CONCLUSION: The increased PMNL count is probably a compensatory response to PMNL priming. The increased rate of superoxide release from primed PMNL may contribute to oxidative stress in early pregnancy.
机译：目的：妊娠期白细胞计数升高的原因尚不清楚。我们假设引发外周多形核白细胞（PMNL）引起此升高。方法：该前瞻性研究包括了妊娠早期三个月的11名妇女。在药物流产之前和之后（分别为怀孕和未怀孕）从每名妇女中抽取两次外周静脉血。确定了全血细胞计数，血浆碱性磷酸酶（ALP）以及从分离的磷酸12-肉豆蔻酸酯-13-乙酸酯（PMA）刺激的PMNL中释放的超氧化物的速率。结果：妊娠早期的PMNL计数显着更高，与未妊娠状态相比，PMNL中的超氧化物释放率显着增加。发现妊娠前和妊娠期间超氧化物释放速率与PMNL计数之间存在线性关系。怀孕早期，ALP水平显着升高。结论：增加的PMNL计数可能是对PMNL启动的补偿性反应。从引发的PMNL中释放的超氧化物的速率增加可能会导致妊娠早期的氧化应激。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号