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首页> 外文期刊>Journal of the Indian Chemical Society >Direct spectrophotometric determination of metronidazole and ornidazole
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Direct spectrophotometric determination of metronidazole and ornidazole

机译：直接光度法测定甲硝唑和奥硝唑

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摘要

A direct spectrophotometric method was developed by the authors, for the detection and determination of metronidazole and ornidazole in pure form, as well in pharmaceutical formulations in the form of tablets and capsules. The method was based on the formation of an instantaneous, clear, stable, reddish-purple colour, due to the diazotization reaction between the nitro group of the drug sample, sulphanilamide and NEDA. The drug sample, dissolved in hot-water, followed by the addition of 2 ml of each 0.5% sulphanilamide and 0.3% NEDA, exhibited a stable reddish purple colour, which showed a maximum absorbance at 540 nm. Beer's law was found to be obeyed in the range of 200-600 μg ml~(-1) for metronidazole and 100-300 μg mL~(-1) for ornidazole with a limit of detection of 0.01 μg mL~(-1) and 0.02 μg mL~(-1) respectively. The method was found to be simple, accurate and recommended for rapid analysis.
机译：作者开发了一种直接分光光度法，用于检测和测定纯形式的甲硝唑和奥硝唑，以及片剂和胶囊剂形式的药物制剂。该方法基于形成瞬时，透明，稳定，红紫色的颜色，这是由于药物样品的硝基，磺胺和NEDA之间的重氮化反应所致。药物样品溶于热水，然后分别加入2 ml的0.5％磺胺和0.3％NEDA，显示稳定的红紫色，在540 nm处显示最大吸光度。甲硝唑的啤酒定律在200-600μgml〜（-1）范围内，奥硝唑的啤酒定律在100-300μgmL〜（-1）范围内，检出限为0.01μgmL〜（-1）和0.02μgmL〜（-1）。发现该方法简单，准确，建议用于快速分析。

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