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首页> 外文期刊>Journal of the Indian Chemical Society >Kinetic spectrophotometric determination of escitalopram oxalate in bulk and pharmaceutical formations using alkaline potassium permanganate
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Kinetic spectrophotometric determination of escitalopram oxalate in bulk and pharmaceutical formations using alkaline potassium permanganate

机译：碱性高锰酸钾动力学分光光度法测定散装和药物制剂中草酸艾司西酞普兰

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摘要

Simple and sensitive kinetic spectrophotometric methods were established for the determination of escitalopram oxalate in bulk and in its pharmaceutical preparations using alkaline potassium permanganate as an oxidizing agent. The methods involve determination of escitalopram Oxalate by kinetic studies of its oxidation at room temperature for a fixed time of 15 min. The absorbance of the colored manganate ions was measured at 610 nm. Alternatively, the decrease in the absorbance of permanganate upon addition of the studied drug was also measured at 525 nm. The absorbance-cohecntration plots in both procedures were rectilinear over the range of 4.0-25.0 μg mL~(-1). The different experimental parameters affecting the development were carefully studied and optimized. The determination of escitalopram oxalate by the fixed concentration and initial rate methods is also feasible with the calibration equations obtained but the fixed time method has been found to be more applicable. Both procedures were applied to the determination of escitalopram oxalate in formulations. The results obtained were in good agreement with those obtained using reference methods. The proposed methods have a great value in their application to the analysis of escitalopram oxalate in quality control laboratories.
机译：建立了简单灵敏的动力学分光光度法，以碱性高锰酸钾为氧化剂测定散装的依他普仑草酸盐及其药物制剂。该方法包括通过在室温下固定时间（15分钟）的动力学研究依他普仑草酸盐的测定。在610nm下测量有色的锰酸根离子的吸光度。或者，在525nm处也测量了加入研究药物后高锰酸盐吸收率的降低。两种方法的吸光度-浓度曲线在4.0-25.0μgmL〜（-1）范围内均为直线。仔细研究和优化了影响开发的不同实验参数。通过固定的浓度和初始速率法测定依他普仑草酸盐也是可行的，但需使用所获得的校准方程式，但已发现固定时间法更为适用。两种方法均用于测定制剂中草酸依地普仑。获得的结果与使用参考方法获得的结果非常吻合。所提出的方法在质量控制实验室对草酸依地普仑的分析中具有重要的应用价值。

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