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首页> 外文期刊>Journal of the Indian Chemical Society >Design and synthesis of NSAIDs derivatives as antioxidant agents
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Design and synthesis of NSAIDs derivatives as antioxidant agents

机译：NSAIDs衍生物作为抗氧化剂的设计与合成

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摘要

An extensive literature review reveals that various NSAIDs, their analogues and hybrids possess anticancer(1) and antioxidant(1-3) properties. The present study aims at designing, docking studies and synthesis of drug hybrids of NSAIDs with other amino compounds linked through dipeptide spacers, which are known for their anticancer as well as cellular penetrating properties. The synthesis was carried out by solution phase method using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or o-(benzotriazol-1-y1)-N,N,N',N'-tetramethyluronium tetrafluoroborate (TBTU) as coupling reagent and triethyl amine (TEA) as a base in chloroform. Antioxidant studies showed that the synthesized NSAID derivatives showed moderate antioxidant activity as compared to the standard, ascorbic acid.
机译：大量文献综述表明，各种NSAID，其类似物和杂种均具有抗癌（1）和抗氧化剂（1-3）的特性。本研究旨在设计，对接研究和合成NSAIDs与通过二肽间隔基连接的其他氨基化合物的药物杂合体，这些杂合体以其抗癌和细胞穿透特性而闻名。使用1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDC）或邻-（苯并三唑-1-y1）-N，N，N'，N'-四甲基铀四氟硼酸酯（TBTU）通过溶液相法进行合成）作为偶联剂，三乙胺（TEA）作为氯仿中的碱。抗氧化剂研究表明，与标准抗坏血酸相比，合成的NSAID衍生物具有中等的抗氧化活性。

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