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首页> 外文期刊>Journal of synchrotron radiation >Detection of circulating tumor cells via an X-ray imaging technique
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Detection of circulating tumor cells via an X-ray imaging technique

机译：通过X射线成像技术检测循环肿瘤细胞

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摘要

Detailed information on the location and the size of tumor cells circulating through lymphatic and blood vessels is useful to cancer diagnosis. Metastasis of cancers to other non-adjacent organs is reported to cause 90% of deaths not from the primary tumors. Therefore, effective detection of circulating tumors cells (CTCs) related to metastasis is emphasized in cancer treatments. With the use of synchrotron X-ray micro-imaging techniques, high-resolution images of individual flowing tumor cells were obtained. Positively charged gold nanoparticles (AuNPs) which were inappropriate for incorporation into human red blood cells were selectively incorporated into tumor cells to enhance the image contrast. This approach enables images of individual cancer cells and temporal movements of CTCs to be captured by the high X-ray absorption efficiency of selectively incorporated AuNPs. This new technology for in vivo imaging of CTCs would contribute to improve cancer diagnosis and cancer therapy prognosis.
机译：通过淋巴管和血管循环的肿瘤细胞的位置和大小的详细信息对于癌症诊断很有用。据报道，癌症转移至其他非相邻器官可导致90％的死亡不是由原发性肿瘤引起的。因此，在癌症治疗中强调有效检测与转移有关的循环肿瘤细胞（CTC）。使用同步加速器X射线显微成像技术，可以获得单个流动的肿瘤细胞的高分辨率图像。将不适合掺入人红细胞的带正电的金纳米颗粒（AuNPs）选择性掺入肿瘤细胞中以增强图像对比度。这种方法可以通过选择性掺入的AuNPs的高X射线吸收效率来捕获单个癌细胞的图像和CTC的时间运动。 CTC体内成像的这项新技术将有助于改善癌症诊断和癌症治疗的预后。

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