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首页> 外文期刊>Journal of the Royal Society Interface >Blood flow through the embryonic heart outflow tract during cardiac looping in HH13-HH18 chicken embryos
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Blood flow through the embryonic heart outflow tract during cardiac looping in HH13-HH18 chicken embryos

机译：在HH13-HH18鸡胚胎的心脏循环过程中，血液流过胚胎心脏流出道

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摘要

Blood flow is inherently linked to embryonic cardiac development, as haemodynamic forces exerted by flow stimulate mechanotransduction mechanisms that modulate cardiac growth and remodelling. This study evaluated blood flow in the embryonic heart outflow tract (OFT) during normal development at each stage between HH13 and HH18 in chicken embryos, in order to characterize changes in haemodynamic conditions during critical cardiac looping transformations. Two-dimensional optical coherence tomography was used to simultaneously acquire both structural and Doppler flow images, in order to extract blood flow velocity and structural information and estimate haemodynamic measures. From HH13 to HH18, peak blood flow rate increased by 2.4-fold and stroke volume increased by 2.1-fold. Wall shear rate (WSR) and lumen diameter data suggest that changes in blood flow during HH13-HH18 may induce a shear-mediated vasodilation response in the OFT. Embryo-specific four-dimensional computational fluid dynamics modelling at HH13 and HH18 complemented experimental observations and indicated heterogeneous WSR distributions over the OFT. Characterizing changes in haemodynamics during cardiac looping will help us better understand the way normal blood flow impacts proper cardiac development.
机译：血流固有地与胚胎心脏发育相关，因为血流施加的血液动力会刺激调节心脏生长和重塑的机械转导机制。这项研究评估了鸡胚HH13和HH18之间每个阶段正常发育过程中胚胎心脏流出道（OFT）的血流量，以表征关键性心脏循环转换过程中血液动力学状况的变化。二维光学相干断层扫描技术可同时获取结构和多普勒血流图像，以提取血流速度和结构信息并估算血液动力学指标。从HH13到HH18，峰值血流量增加了2.4倍，中风量增加了2.1倍。壁切变率（WSR）和管腔直径数据表明，在HH13-HH18期间血流的变化可能会在OFT中引起切变介导的血管舒张反应。 HH13和HH18的特定于胚胎的三维计算流体动力学模型补充了实验观察结果，并指出了OFT上的异质WSR分布。表征心脏循环过程中血流动力学的变化将有助于我们更好地了解正常血流影响正常心脏发育的方式。

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