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首页> 外文期刊>Journal of Veterinary Dentistry >Immunohistochemical Analysis of a Dentigerous Cyst in a Dog
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Immunohistochemical Analysis of a Dentigerous Cyst in a Dog

机译：犬齿囊肿的免疫组织化学分析

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A dentigerous cyst is a cyst that encloses part or the entire crown of an impacted or late-erupting tooth and occurs with comparatively high frequency in humans. In animals, there are three different lesions that are similar to dentigerous cyst and this complexity has led to confusion. In order to clarify the dentigerous cyst most similar to that in humans especially with regard to characteristics of the lining epithelium, this report describes the clinical, pathological, and immunohistochemical features of a dentigerous cyst in a dog. Further, approaches to the surgical and dental management of this cyst in dogs are also discussed and the literature is reviewed. Extraction of an embedded right mandibular first premolar tooth and debridement of thedentigerous cyst soft tissue lining were performed in a 4-year-old female mixed-breed dog. Radiography showed a well-defined unilocular and radiolucent area associated with the crown of the unerupted tooth. Histologically, the unilocular cyst wall was mainly lined by non-keratinized stratified flattened epithelium. As in humans, canine dentigerous cyst can be appropriately treated by cyst enudeation after accurate diagnosis. The radiographic appearance of an unerupted tooth embedded in an osseous cyst wall is a significant characteristic finding. Moreover, non-keratinized epithelium is immunoreactive for amelogenin and ssDNA, which might be associated with deregulation of cell death in the lining epithelium, derived from odontogenic origin. When encountering any questionable lesions, an accurate diagnosis and immediate treatment can avoid malignant transformation.
机译：牙本质囊肿是一种囊肿，囊括了受累或萌发的牙齿的一部分或整个冠，并在人类中以较高的频率出现。在动物中，有三种不同的病变与牙周囊肿相似，这种复杂性导致混乱。为了阐明与人类最相似的齿状囊肿，特别是关于衬里上皮的特征，本报告描述了犬齿状囊肿的临床，病理和免疫组织化学特征。此外，还讨论了在犬中对该囊肿进行手术和牙科处理的方法，并对文献进行了回顾。在4岁的雌性混血犬中进行埋入的右下颌第一磨牙的拔除术和清除囊肿性软组织衬里的清创术。放射线检查显示与未拔牙牙冠相关的明确的单眼和射线可透区域。从组织学上讲，单眼囊壁主要被未角化的分层扁平上皮所衬。与人类一样，在准确诊断后，可以通过包囊渗出术适当治疗犬齿状囊肿。埋在骨囊肿壁中的直齿的放射照相外观是一项重要的特征发现。此外，未角化的上皮对牙釉蛋白和ssDNA具有免疫反应性，这可能与源自牙源性起源的衬里上皮细胞死亡调节失调有关。当遇到任何可疑的病变时，准确的诊断和立即治疗可以避免恶变。

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