• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Veterinary Dentistry >Immunohistochemical Localization of Osteoclastogenic Cell Mediators in Feline Tooth Resorption and Healthy Teeth
【24h】

Immunohistochemical Localization of Osteoclastogenic Cell Mediators in Feline Tooth Resorption and Healthy Teeth

机译：破骨细胞生成介体在猫牙齿吸收和健康牙齿中的免疫组织化学定位

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tooth resorption is among the most common and most challenginii problems in feline denlistiy. It a progivssive disease eventually leading to tooth loss and often root replacetnent. The etiology of tooth resorption remains obscure and to date no effective therapeutic approach is fxnown. Tfie present study is aimed at assessing the reliability of radiographic imaging and addressing the possible involvement of receptor activator of XFa'B (fLl.XK), its ligand (RANKL), and osteopmtegerin (OPG) in the process of tooth resorption. Teeth fnm H cats were imestigated h' means of mdiograplis and paraffin sections followed by immimolalx'ling. Six cats were diagnosed with tooth resorption based on histopathologic and radiographic findings. Samples were classified according to a four-stage diagnostic system, fiadiologic assessment of tooth resoiption correlated veiy strongly with histopathologic findings. Tooth resorption was accompanied by a stmng staining with all three antibodies used, especially with anti-RA.NK and anli-RANKL antibodies. The p/vsence of OPG and R.ANKL at the resorption .site is indicative of repair attempts by filvy)blasts and stivmal cells. Tfiese findings should he extended by furilier investigations in order to elucidate the patfio-physiologic proces.ses underlying tooth resorption that might lead to prophylactic and/or therapeutic measures.
机译：牙齿吸收是猫牙齿矫治中最常见和最棘手的问题之一。它是一种繁殖性疾病，最终导致牙齿脱落，并经常引起牙根置换。牙齿吸收的病因仍然不清楚，迄今为止还没有有效的治疗方法。本研究旨在评估放射成像的可靠性，并解决XFa'B受体激活剂（fLl.XK），其配体（RANKL）和骨结合蛋白（OPG）在牙齿吸收过程中的可能参与。用平皿和石蜡切片的方式对fnm H猫进行了牙学检查，然后进行了immimolalx'ling。根据组织病理学和影像学发现，六只猫被诊断出牙齿吸收。根据四阶段诊断系统对样品进行分类，牙齿再吸的纤维化学评估与组织病理学发现密切相关。所用的所有三种抗体，尤其是抗RA.NK和anli-RANKL抗体，均伴随着牙齿的吸收而被牙齿吸收。 OPG和R.ANKL在再吸收位点的存在表明了原纤维和胚细胞的修复尝试。为了进一步阐明可能导致预防和/或治疗措施的牙齿吸收的基础生理过程，应该通过进一步的调查来扩展这些发现。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号