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首页> 外文期刊>Journal of Veterinary Dentistry >Canine periodontal disease control using a clindamycin hydrochloride gel.
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Canine periodontal disease control using a clindamycin hydrochloride gel.

机译：使用盐酸克林霉素凝胶控制犬牙周疾病。

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摘要

Stabilizing or reducing periodontal pocket depth can have a positive influence on the retention of teeth in dogs. A topical 2% clindamycin hydrochloride gel (CHgel) was evaluated for the treatment of periodontal disease in dogs. The CHgel formulation provides for the sustained erosion of the matrix, but also flows into the periodontal pocket as a viscous liquid, and then rapidly forms a gel that has mucoadhesive properties and also may function as a physical barrier to the introduction of bacteria. A professional teeth cleaning procedure including scaling and root planing was done in dogs with one group receiving CHgel following treatment. Periodontal health was determined before and after the procedure including measurement of periodontal pocket depth, gingival index, gingival bleeding sites, and number of suppurating sites. There was a statistically significant decrease in periodontal pocket depth (19%), gingival index (16%), and the number of bleeding sites (64%) at 90-days in dogs receiving CHgel. Additionally, the number of suppurating sites was lower (93%) at 90-days for the group receiving CHgel. The addition of CHgel effectively controlled the bacterial burden (e.g, Fusobacterium nucleatum) at both day 14 and 90. Gingival cells in culture were shown to rapidly incorporate clindamycin and attain saturation in approximately 20-minutes. In summary, a professional teeth cleaning procedure including root planning and the addition of CHgel improves the gingival index and reduces periodontal pocket depth.
机译：稳定或减少牙周袋深度可对狗的牙齿保持产生积极影响。评价局部用2％盐酸克林霉素凝胶（CHgel）治疗犬牙周疾病。 CHgel制剂可持续侵蚀基质，但也以粘性液体的形式流入牙周袋，然后迅速形成具有粘膜粘附特性​​的凝胶，并可能对细菌的引入起到物理屏障的作用。对狗进行了专业的牙齿清洁程序，包括洗牙和根部平整，一组在治疗后接受CHgel。在手术前后确定牙周健康状况，包括测量牙周袋深度，牙龈指数，牙龈出血部位和化脓部位的数量。接受CHgel的狗在90天时，牙周袋深度（19％），牙龈指数（16％）和出血部位数量（64％）的减少有统计学意义。此外，接受CHgel治疗的组在90天时化脓部位的数量较少（93％）。 CHgel的添加在第14天和第90天都能有效控制细菌负荷（例如，核梭形杆菌）。培养物中的牙龈细胞已显示出迅速掺入克林霉素并在约20分钟内达到饱和。总之，包括根部规划和添加CHgel在内的专业牙齿清洁程序可改善牙龈指数并减少牙周袋深度。

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