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首页> 外文期刊>Journal of Veterinary Dentistry >Polyamine Inhibitors for Treatment of Feline Oral Squamous Cell Carcinoma: A Proof-of-Concept Study
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Polyamine Inhibitors for Treatment of Feline Oral Squamous Cell Carcinoma: A Proof-of-Concept Study

机译：多胺抑制剂治疗猫口腔鳞状细胞癌的概念验证研究。

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摘要

This study assessed proof-of-concept for use of polyamine inhibitor 2-difluoromethylornithine (DFMO) as a treatment for oral squamous cell carcinoma (SCC) in client-owned cats. Polyamine levels in tumor tissue and normal oral mucosa were quantified before and after treatment. DFMO was administered orally to 14 client-owned cats with histologically confirmed oral SCC. Patients were monitored for gastrointestinal, dermatologic, auditory, hematological, and biochemical abnormalities. Total polyamine levels in tumor tissue decreased after treatment, as did the specific polyamine putrescine in both tumor tissue and normal mucosa. Ototoxicity was observed in 5 of 6 cats receiving pre- and post-treatment brainstem auditory evoked potential tests. Subclinical thrombocytopenia was observed in 6 of 14 cats. One cat showed mild post-anesthetic tremors that resolved without treatment. Oral administration of DFMO at doses used in this study resulted in significantly decreased tumor polyamine levels without life-threatening clinical or hematological toxicities. Further studies are warranted to explore pathophysiology of polyamine biochemistry and use of polyamine inhibitors in treatment of cats with oral SCC.
机译：这项研究评估了使用多胺抑制剂2-二氟甲基鸟氨酸（DFMO）来治疗自有家猫的口腔鳞状细胞癌（SCC）的概念验证。在治疗之前和之后对肿瘤组织和正常口腔粘膜中的多胺水平进行定量。经组织学证实为口服SCC的DFMO口服给14只客户拥有的猫。监测患者的胃肠道，皮肤病学，听觉，血液学和生化异常。治疗后肿瘤组织中的总多胺水平降低，肿瘤组织和正常粘膜中的特定多胺腐胺也一样。在接受治疗前后脑干听觉诱发电位测试的6只猫中，有5只猫观察到了耳毒性。在14只猫中的6只中观察到亚临床性血小板减少症。一只猫表现出轻度的麻醉后震颤，无需治疗即可缓解。以这项研究使用的剂量口服DFMO可以显着降低肿瘤中的多胺水平，而不会危及生命，不会影响临床或血液学毒性。有必要进行进一步的研究以探索多胺生物化学的病理生理学，以及多胺抑制剂在口服SCC治疗猫中的用途。

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