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The physiological significance of negative cooperativity revisited

机译：重新探讨负合作性的生理意义

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More than 35 years ago I wrote a Letter to the Editor in this Journal (Cornish-Bowden, 1975) with almost the same title as the present one. At that time the possible physiological advantages of negative cooperativity were obscure, in part because virtually all the emphasis when discussing regulation of enzymes was on individual enzymes that were supposedly rate-limiting. Although a more rational approach, in which enzymes are recognized to be components of systems, had already been advocated (Kacser and Burns, 1973; Heinrich and Rapoport, 1974),1 this had almost no impact on biochemical thinking at the beginning (Cornish-Bowden, 1996, 2008). Only in the past two decades has it become widely accepted that metabolic regulation can only be understood in the context of whole systems (Hofmeyr and Cornish-Bowden, 1991). Even today, the concept of a rate-limiting step remains widespread: Morandini (2009) has thoroughly documented its continued popularity in plant biochemistry, and there is little doubt that similar reviews could be written in the context of animal and microbial biochemistry.
机译：35年前，我在《日刊》上写了一封给编辑的信（Cornish-Bowden，1975年），标题与现在的差不多。那时，负协同作用的可能的生理优势尚不清楚，部分原因是实际上，在讨论酶的调节时，实际上所有重点都放在据称是限速酶上。尽管已经提出了一种更为合理的方法，即认为酶被认为是系统的组成部分（Kacser和Burns，1973年; Heinrich和Rapoport，1974年）1，但一开始对生化思维几乎没有影响（Cornish- Bowden，1996，2008）。仅在过去的二十年中，代谢调控才可以在整个系统的背景下被广泛接受（Hofmeyr和Cornish-Bowden，1991）。即使在今天，限速步骤的概念仍然广泛存在：Morandini（2009）充分证明了其在植物生物化学中的持续流行，毫无疑问，类似的评论可以在动物和微生物生物化学的背景下进行。

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