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首页> 外文期刊>Journal of Theoretical Biology >System-theoretical (Holistic) approach to the modelling of structural-functional relationships of biomolecules and their evolution: an example of triterpene glycosides from sea cucumbers (Echinodermata, Holothurioidea)
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System-theoretical (Holistic) approach to the modelling of structural-functional relationships of biomolecules and their evolution: an example of triterpene glycosides from sea cucumbers (Echinodermata, Holothurioidea)

机译：系统理论（整体）方法对生物分子及其进化的结构-功能关系进行建模：海参中三萜糖苷的一个实例（棘皮类，全鳞类）

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Triterpene glycosides from sea cucumbers (Holothurioidea, Echinodermata) are used as a model for studying the biochemical evolution for correlation between the glycoside membranolytic activity and biological functions. Concepts of evolutionary morphology are applied at the molecular level. The concept of Van-der-Klaauve's-Dullemeijer's system-theoretical (holistic) approach is used for the model of structural-functional relationships of the glycosides. Network diagrams of structural-functional relationships have been prepared for many glycosides. The diagrams correlate well with experimental data and show a very complex and flexible action of the natural selection on the structural fragments of the glycosides. The diagrams also show overlapping in the functional components that provide stability to the general structural plan of glycosides during evolution. The method may be applied to other bio molecules. (C) 2000 Academic Press. [References: 50]
机译：海参（Holothurioidea，Echinodermata）中的三萜糖苷被用作研究糖苷膜分解活性与生物学功能之间相关性的生化进化的模型。进化形态学的概念在分子水平上得到应用。 Van-der-Klaauve's-Dullemeijer的系统理论（整体）方法的概念用于糖苷的结构-功能关系模型。已经为许多糖苷制备了结构-功能关系的网络图。该图与实验数据很好地相关，并且显示了天然选择对糖苷的结构片段的非常复杂和灵活的作用。该图还显示了在进化过程中为糖苷的总体结构计划提供稳定性的功能成分的重叠。该方法可以应用于其他生物分子。 （C）2000学术出版社。 [参考：50]

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