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首页> 外文期刊>Journal of Theoretical Biology >Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: Tapered T-tube model analysis
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Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: Tapered T-tube model analysis

机译：链脲佐菌素诱导的正常血压糖尿病大鼠血管动力学受损：锥形T型管模型分析

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This study is to explore the changes of arterial mechanical properties in streptozotocin (STZ)-diabetic rats, based on the exponentially tapered T-tube model. Rats given STZ 65 mg kg(-1) i.v. are compared with untreated weight- and age-matched controls. A high-fidelity pressure sensor and electromagnetic flow probe measured pulsatile pressure and flow waves in the ascending aorta, respectively. Diabetic rats exhibit isobaric vasodilatation that is characterized by an increase in cardiac output and no significant changes in aortic pressure. Total peripheral resistance of diabetic rats is lower than that of weight- and age-matched controls. Diabetic rats have higher total peripheral compliance (2.86 +/- 0.70 mu l mmHg(-1)) than do weight- (1.77 +/- 0.34 mu l mmHg(-1)) and age-matched (1.87 +/- 0.69 mu l mmHg(-1)) controls. Aortic characteristic impedance is reduced from 0.017 +/- 0.003 mmHg min kg ml(-1) in weight- and 0.020 +/- 0.004 mmHg min kg ml(-1) in age-matched controls to 0.010 +/- 0.004 mmHg min kg ml(-1) in diabetic rats. Moreover, diabetic rats show shorter wave transit time in lower body circulation (17.86 +/- 1.91 ms) than do weight- (20.45 +/- 1.91) and age-matched (23.05 +/- 2.04 ms) controls. Under isobaric vasodilatation, the decreased resistance and increased compliance in peripheral circulation suggest that the contractile dysfunction of the smooth muscle cells may occur in resistance arterioles in diabetes. With unaltered aortic pressure, an impairment in aortic distensibility of STZ-diabetic rats is manifest on the reduced wave transit time rather than on the diminished aortic characteristic impedance. (C) 2000 Academic Press. [References: 28]
机译：这项研究旨在探索基于指数锥形T管模型的链脲佐菌素（STZ）糖尿病大鼠的动脉力学特性的变化。静脉给予STZ 65 mg kg（-1）的大鼠。与未治疗的体重和年龄相匹配的对照进行比较。高保真压力传感器和电磁流量探头分别测量升主动脉中的搏动压力和流动波。糖尿病大鼠表现出等压血管舒张，其特征是心输出量增加，主动脉压无明显变化。糖尿病大鼠的总外周抵抗力低于体重和年龄相匹配的对照组。糖尿病大鼠的总外周顺应性（2.86 +/- 0.70μlmmHg（-1））高于体重（1.77 +/- 0.34μlmmHg（-1））和年龄相匹配的（1.87 +/- 0.69 mu） l mmHg（-1））控件。主动脉特征阻抗从体重匹配的0.017 +/- 0.003 mmHg min kg ml（-1）和年龄匹配的对照组中的0.020 +/- 0.004 mmHg min kg ml（-1）降至0.010 +/- 0.004 mmHg min kg ml（-1）在糖尿病大鼠中。此外，糖尿病大鼠在下半身循环中的波传播时间（17.86 +/- 1.91 ms）比体重（20.45 +/- 1.91）和年龄相匹配的（23.05 +/- 2.04 ms）短。在等压血管舒张下，抵抗力的降低和外周循环顺应性的增加表明，糖尿病患者的抵抗小动脉中可能发生平滑肌细胞的收缩功能障碍。在主动脉压力未改变的情况下，STZ糖尿病大鼠的主动脉扩张性受损表现为减少的波传播时间，而不是主动脉特征阻抗降低。 （C）2000学术出版社。 [参考：28]

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