...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Theoretical Biology >Evaluation of pathways for progression of heterogeneous breast tumors
【24h】

Evaluation of pathways for progression of heterogeneous breast tumors

机译：评价异质性乳腺肿瘤进展的途径

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To better understand the progression of heterogeneous breast cancers, four models of progession pathways have been evaluated. The models describe the progression through the grades of ductal carcinoma in situ (DIS) 1, 2, and 3, and through the grades of invasive ductal carcinoma (IDC) 1, 2, and 3. The first three pathways, termed linear, nonlinear, and branched, describe DCIS as a progenitor of IDC, and grades of DCIS progressing into grades of IDC. The fourth pathway, termed parallel, describes DCIS and IDC as diverging from a common progenitor and progressing through grades in parallel. The best transition rates for the linear, nonlinear, and branched pathways were sought using a random search in combination with a directed search based on the Nelder-Mead simplex method. Parameter values for the parallel pathway were determined with heuristic graphs. Results of computer simulation were compared with clinically observed frequencies of grades of DCIS and grades of IDC that were reported to occur together in heterogeneous tumors. Each of the four pathways could simulate frequencies that resembled, to varying degrees, the clinical observations. The parallel pathway produced the best correspondence with clinical observations. These results quantify the traditional descriptions in which grades of DOS are the progenitors of grades of IDC. The results also raise the alternative possibility that, in some tumors with both components, DCIS and IDC may have diverged from a common progenitor. (C) 2004 Published by Elsevier Ltd.
机译：为了更好地了解异源性乳腺癌的进展，已评估了四种进展途径模型。这些模型描述了通过导管原位癌（DIS）1、2和3的等级以及通过浸润性导管癌（IDC）1、2和3的等级的进展。前三种途径称为线性，非线性，然后分支，将DCIS描述为IDC的前身，然后将DCIS的等级升级为IDC的等级。第四个途径称为并行，它描述了DCIS和IDC与共同的祖先背道而驰，同时并行进行了各个等级。使用随机搜索结合基于Nelder-Mead单纯形法的定向搜索，寻求线性，非线性和分支路径的最佳过渡速率。平行路径的参数值由启发式图表确定。将计算机模拟结果与临床观察到的DCIS等级和IDC等级的频率进行了比较，据报道这些频率在异质性肿瘤中同时发生。四个途径中的每一个都可以模拟在不同程度上类似于临床观察结果的频率。平行途径产生了与临床观察的最佳对应。这些结果量化了传统描述，其中DOS等级是IDC等级的前身。该结果还提出了另一种可能性，即在某些同时具有两种成分的肿瘤中，DCIS和IDC可能偏离了一个共同的祖细胞。 （C）2004由Elsevier Ltd.出版

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号