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首页> 外文期刊>Journal of Theoretical Biology >Background selection and population differentiation
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Background selection and population differentiation

机译：背景选择和人口分化

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A general analytical formula is derived, which predicts the effects of background selection on population differentiation at a neutral locus as a result of its linkage with selected loci of deleterious mutations. The theory is based on the assumptions of random mating, multiplicative fitness, and weak selection in hermaphrodite plants in the island model of population structure. The analytical results show that F-st at the neutral locus increases as a result of the effects of background selection, regardless of the dependence or independence among linked background selective loci. The increment in F-st is closely related to the magnitude of linkage disequilibria between the neutral locus and selected loci, and can be estimated by the ratio of F-st with background selection to F-st without background selection minus one. The steady-state linkage disequilibrium between a neutral locus and a selected locus in subpopulations, primarily attained by gene flow, decreases with the recombination rate, and can be enhanced when there are dependence among linked selected loci. Monte Carlo computer simulations with two- and three-locus models show that the analytical formulae perform well under general conditions. Application of the present theory may aid in analyzing the genome-wide mapping of the effect of background selection in terms of F-st. (c) 2005 Elsevier Ltd. All rights reserved.
机译：推导了一个通用分析公式，该公式预测了背景选择对中性位点种群分化的影响，这是因为背景选择与有害突变的选定基因座相关。该理论基于种群结构岛模型中雌雄同体植物中随机交配，乘法适应性和弱选择的假设。分析结果表明，由于背景选择的影响，中性基因座处的F-st增加，而与链接的背景选择基因座之间的依赖性或独立性无关。 F-st的增加与中性基因座与选定基因座之间连锁不平衡的程度密切相关，并且可以通过具有背景选择的F-st与没有背景选择的F-st的比值减去1来估算。亚群中的中性基因座和选定基因座之间的稳态连锁不平衡，主要是通过基因流获得的，随着重组率的降低而降低，当在连锁的选定基因座之间存在依赖性时，平衡态不平衡会加剧。具有两位置和三位置模型的蒙特卡洛计算机仿真表明，该解析公式在一般条件下表现良好。本理论的应用可以帮助分析根据F-st对背景选择的影响的全基因组作图。 （c）2005 Elsevier Ltd.保留所有权利。

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