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首页> 外文期刊>Journal of Theoretical Biology >Modeling the interaction of peroxynitrite with low-density lipoproteins. I. Plasma levels of peroxynitrite
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Modeling the interaction of peroxynitrite with low-density lipoproteins. I. Plasma levels of peroxynitrite

机译:模拟过氧亚硝酸盐与低密度脂蛋白的相互作用。 I.过氧亚硝酸盐的血浆水平

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Peroxynitrite is a strong candidate for the material responsible for the initiation of peroxidation of low-density lipoproteins (LDLs) which is considered the first step in the formation of atherosclerotic plaque. Recent advances in the understanding of peroxynitrite chemistry allow the construction of a kinetic model that can be used to understand the factors controlling levels in plasma. These results indicate that the carbon dioxide catalysed decomposition of peroxynitrite produces large quantities of reactive species, but the rapid decomposition of this intermediate, ONOOCO2-, may limit its availability to attack LDLs at points distant from the site of production. In this case, peroxynitrite itself may be of greater quantitative importance in LDL peroxidation. (C) 2000 Academic Press. [References: 32]
机译:过氧亚硝酸盐是负责引发低密度脂蛋白(LDL)过氧化的物质的强候选者,这被认为是形成动脉粥样硬化斑块的第一步。对过氧亚硝酸盐化学的理解的最新进展允许构建动力学模型,该动力学模型可用于理解控制血浆中水平的因素。这些结果表明,二氧化碳催化过氧亚硝酸盐的分解会产生大量的反应性物质,但是这种中间体ONOOCO2-的快速分解可能会限制其在远离生产地点的位置攻击LDL的可用性。在这种情况下,过氧亚硝酸盐本身在LDL过氧化中可能具有更大的定量重要性。 (C)2000学术出版社。 [参考:32]

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