...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Theoretical Biology >Co-Evolution of the Genetic Code and Ribozyme Replication.
【24h】

Co-Evolution of the Genetic Code and Ribozyme Replication.

机译：遗传密码和核酶复制的共同进化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The origin of translation has stimulated much discussion since the basic processes involved were deciphered during the 1960s and 1970s. One strand of thought suggested that the process originated from RNA replication in the RNA world (Weiner & Maizels, 1987, 1994). In this paper I seek to extend this model. The mRNA originates as a replication intermediate of minus-strand ribozyme replication and thus contains all the genetic information contained in both the ribozyme portion and the putative tRNA-like portion of the RNA molecule. Qualitatively, this is similar to the model for the origin of chromosomes (Szathmary & Maynard-Smith, 1993, Maynard-Smith & Szathmary, 1993). This model explicitly describes the evolution of early chromosomes and the role replication played in generating the modern mRNA. Moreover, by pursuing this model, the START and STOP codons were derived and their original function with regard to the primitive 23S ribosomal RNA is suggested. Co-evolution of the genetic code (Wong, 1975) is also contained within the model. Lastly, I address some of the benefits and costs that the process may have for the organism in the context of autotrophy in the RNA world.
机译：自从1960年代和1970年代破译了涉及的基本过程以来，翻译的起源就引起了很多讨论。一连串的想法表明，这一过程起源于RNA世界中的RNA复制（Weiner＆Maizels，1987，1994）。在本文中，我试图扩展这种模型。 mRNA起源于负链核酶复制的复制中间，因此包含了RNA分子的核酶部分和推定的tRNA样部分中包含的所有遗传信息。从性质上讲，这类似于染色体起源的模型（Szathmary和Maynard-Smith，1993; Maynard-Smith和Szathmary，1993）。该模型明确描述了早期染色体的进化以及复制在生成现代mRNA中所起的作用。此外，通过采用该模型，推导了START和STOP密码子，并提出了它们对原始23S核糖体RNA的原始功能。模型中还包含遗传密码的共同进化（Wong，1975）。最后，我讨论了在RNA世界的自养过程中该过程可能给生物带来的一些收益和成本。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号