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首页> 外文期刊>Journal of Theoretical Biology >Markers of Disease Evolution: The Case of Tuberculosis.
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Markers of Disease Evolution: The Case of Tuberculosis.

机译:疾病演变的标志:结核病。

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摘要

Abrupt changes in environmental conditions-broadly understood to include demographic and social dynamics-can seriously impact the local or global disease dynamics of a population. These changes in the evolutionary landscape, which may occur over relatively short time-scales, are very likely to play a critical role in disease evolution. The potential impact of demographic, social and epidemiological shifts on the evolution of tuberculosis epidemics in the United States over the past century and a half is the main subject of this article. Evidence is provided to support the hypothesis that the observed substantial decreases in the incidence of active tuberculosis are the result of abrupt reductions in the rates of disease progression. Copyright 2002 Elsevier Science Ltd. All rights reserved.
机译:环境条件的突然变化(通常被理解为包括人口和社会动态)会严重影响人口的本地或全球疾病动态。这些进化态势的变化可能发生在相对较短的时间范围内,很可能在疾病进化中起关键作用。在过去的一个半世纪中,人口,社会和流行病学变化对美国结核病流行演变的潜在影响是本文的主题。提供了证据支持这一假设,即观察到的活动性肺结核发病率大幅下降是疾病进展速度突然下降的结果。版权所有2002 Elsevier ScienceLtd。保留所有权利。

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