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首页> 外文期刊>Journal of Theoretical Biology >The transition from differential equations to Boolean networks: a case study in simplifying a regulatory network model.
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The transition from differential equations to Boolean networks: a case study in simplifying a regulatory network model.

机译：从微分方程到布尔网络的过渡：简化监管网络模型的案例研究。

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摘要

Methods for modeling cellular regulatory networks as diverse as differential equations and Boolean networks co-exist, however, without much closer correspondence to each other. With the example system of the fission yeast cell cycle control network, we here discuss these two approaches with respect to each other. We find that a Boolean network model can be formulated as a specific coarse-grained limit of the more detailed differential equations model for this system. This demonstrates the mathematical foundation on which Boolean networks can be applied to biological regulatory networks in a controlled way.
机译：然而，共存的用于建立模型模型（如微分方程和布尔网络）的方法彼此之间没有更紧密的对应关系。以裂变酵母细胞周期控制网络的示例系统为例，我们在此相互讨论这两种方法。我们发现布尔网络模型可以公式化为该系统更详细的微分方程模型的特定粗粒度极限。这证明了布尔网络可以以受控方式应用于生物监管网络的数学基础。

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