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首页> 外文期刊>Journal of Theoretical Biology >Diastolic ventricular aspiration: a mechanism supporting the rapid filling phase of the human ventricles.
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Diastolic ventricular aspiration: a mechanism supporting the rapid filling phase of the human ventricles.

机译：舒张性心室吸引：一种支持人心室快速充盈阶段的机制。

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摘要

During the rapid filling phase of the heart cycle, the internal volumes of the two ventricular cavities approximately double, while the intraventricular pressures rise typically only by an amount of less than 1 kPa. Such a small pressure increase cannot be the sole driving mechanism for the large inflow of blood associated with ventricular expansion during this period. Instead, the rapid filling phase is to be interpreted as being mediated primarily by the heart recoiling elastically from its contracted state, causing blood to be aspirated rapidly into the ventricles. In order to study the role of this mechanism, elastic finite element (FE) simulations of ventricular expansion were performed, taking into account the large deformations occurring during this period and the effective compressibility of the myocardium due to intramural fluid flow. Thereby, a realistic three-dimensional geometry derived from magnetic resonance imaging (MRI) measurements of both human ventricles was used. To validate our FE analyses, the results were compared with published measurements relating to the rapid filling phase of the human left ventricle. Our study shows that, under normal physiological conditions, ventricular aspiration plays a key role in the ventricular filling process.
机译：在心动周期的快速充盈阶段，两个心室腔的内部容积大约增加一倍，而心室内压通常仅上升小于1 kPa的量。在此期间，如此小的压力增加不能成为与心室扩张相关的大量血液流入的唯一驱动机制。取而代之的是，快速充盈阶段应解释为主要由心脏从其收缩状态弹性回缩所介导，从而使血液迅速被吸入心室。为了研究这种机制的作用，考虑到在此期间发生的大变形以及由于壁内流体流动引起的心肌的有效可压缩性，进行了心室扩张的弹性有限元（FE）模拟。因此，使用了源自两个人心室的磁共振成像（MRI）测量结果的逼真的三维几何形状。为了验证我们的有限元分析，将结果与已发表的有关人类左心室快速充盈期的测量结果进行了比较。我们的研究表明，在正常生理条件下，心室抽吸在心室充盈过程中起关键作用。

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