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首页> 外文期刊>Journal of Theoretical Biology >An old paper revisited: 'a mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load' by V.V. Dynnik, R. Heinrich and E.E. Sel'kov.
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An old paper revisited: 'a mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load' by V.V. Dynnik, R. Heinrich and E.E. Sel'kov.

机译:V.V. V.V.回顾了一篇旧论文:“碳水化合物能量代谢的数学模型。糖酵解,克雷布斯循环和H-运输穿梭在不同的ATP酶负荷之间的相互作用”。 Dynnik,R.Heinrich和E.E. Sel'kov。

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摘要

We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel'kov (1980a,b) describing: "A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load". We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the structure of the metabolic network in terms of elementary flux modes. We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles.
机译:我们重温V.V. Dynnik,R。Heinrich和E.E. Sel'kov(1980a,b)描述:“碳水化合物能量代谢的数学模型。糖酵解,克雷布斯循环和H-运输穿梭在不同的ATP酶负荷之间的相互作用”。我们对模型进行数学分析,并计算作为ATPase负荷函数的控制系数。我们还根据基本通量模式评估了代谢网络的结构。我们展示了该模型如何响应ATPase负荷以及葡萄糖供应。我们还展示了这个简单的模型如何帮助理解高能代谢的主要模块之间的衔接,即糖酵解,克雷布斯循环和H转运穿梭。

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