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首页> 外文期刊>Journal of Theoretical Biology >Predictive modeling of siderphore production by Pseudomonas fluorescens under iron limitation
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Predictive modeling of siderphore production by Pseudomonas fluorescens under iron limitation

机译：铁限制条件下荧光假单胞菌生产铁载体的预测模型

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摘要

Iron is required by many microorganisms for growth. Although it is the most abundant transition metal on earth, its solubility is very low and therefore its bioavailability is poor. To overcome this limitation, many microorganisms have developed iron chelating mechanisms that enable them to bind the metal to organic molecules from which they are later released. In particular, pseudomonads are prominent producers of the chelator pyoverdine that has a high iron binding capability. We present a mathematical model for pyoverdine production by Pseudomonas fluorescens. It is a nonlinear and non-autonomous system of four ordinary differential equations for the dependent variables size of bacterial population, pyoverdine, dissolved iron and chelated iron. The transient adaptation of the average physiological state of the population to the environmental condition is explicitly included in the model formulation. A complete qualitative description of the model solution is given, based on analytical techniques. The model is quantitatively validated against experimental data of pyoverdine and population size. To this end we conduct and discuss a parameter identification study. It is found that the model, if calibrated using pyoverdine data alone is able to predict the population size and vice versa, with some restrictions. Thus the model can be used as an indirect experimental tool. (C) 2007 Elsevier Ltd. All rights reserved.
机译：铁是许多微生物生长所必需的。尽管它是地球上含量最高的过渡金属，但其溶解度非常低，因此其生物利用度很差。为了克服这一限制，许多微生物已经开发出铁螯合机制，使它们能够将金属与随后释放它们的有机分子结合。特别地，假单胞菌是具有高铁结合能力的螯合剂吡啶酮的重要生产者。我们提出了荧光假单胞菌生产嘧啶的数学模型。它是一个由四个常微分方程组成的非线性非自治系统，用于细菌种群，嘧啶定，溶解铁和螯合铁的因变量大小。人口平均生理状态对环境条件的短暂适应明确包含在模型公式中。基于分析技术，给出了模型解决方案的完整定性描述。该模型针对吡over定和人口规模的实验数据进行了定量验证。为此，我们进行并讨论了参数识别研究。已经发现，如果仅使用pyoverdine数据进行校准，则该模型可以预测人口规模，反之亦然，但有一些限制。因此，该模型可以用作间接实验工具。 （C）2007 Elsevier Ltd.保留所有权利。

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