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首页> 外文期刊>Journal of Theoretical Biology >A 3-D model used to explore how cell adhesion and stiffness affect cell sorting and movement in multicellular systems.
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A 3-D model used to explore how cell adhesion and stiffness affect cell sorting and movement in multicellular systems.

机译：一种3-D模型，用于探索细胞粘附和硬度如何影响多细胞系统中的细胞分类和运动。

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摘要

A three-dimensional mathematical model is used to determine the effects of adhesion and cell signalling on cell movements during the aggregation and slug stages of Dictyostelium discoideum (Dd) and to visualize cell sorting. The building blocks of the model are individual deformable ellipsoidal cells, where movement depends on internal parameter state (cell size and stiffness) and on external cues from the neighboring cells, extracellular matrix, and chemical signals. Cell movement and deformation are calculated from equations of motion using the total force acting on each cell, ensuring that forces are balanced. The simulations show that the sorting patterns of prestalk and prespore cells, emerging during the slug stage, depend critically on the type of cell adhesion and not just on chemotactic differences between cells. This occurs because cell size and stiffness can prevent the otherwise faster cells from passing the slower cells. The patterns are distinctively different when the prestalk cells are more or less adhesive than the prespore cells. These simulations suggest that sorting is not solely due to differential chemotaxis, and that differences in both adhesion strength and type between different cell types play a very significant role, both in Dictyostelium and other systems.
机译：三维数学模型用于确定粘着性盘基网柄菌（Dd）的聚集和段塞阶段粘附和细胞信号传导对细胞运动的影响，并可视化细胞分选。该模型的构建块是单个可变形的椭圆形细胞，其运动取决于内部参数状态（细胞大小和刚度）以及来自相邻细胞，细胞外基质和化学信号的外部提示。使用作用在每个单元格上的总力，根据运动方程式计算单元格的运动和变形，确保力平衡。模拟表明，在the期出现的茎和芽孢细胞的分选模式主要取决于细胞粘附的类型，而不仅取决于细胞之间的趋化差异。发生这种情况是因为像元大小和刚度会阻止原本更快的像元通过较慢的像元。当前茎细胞比芽孢细胞或多或少具有粘附性时，图案明显不同。这些模拟表明，分类不仅是由于趋化性的差异，而且在双歧杆菌和其他系统中，不同细胞类型之间粘附强度和类型的差异也起着非常重要的作用。

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