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首页> 外文期刊>Journal of Theoretical Biology >Modeling absence seizure dynamics: implications for basic mechanisms and measurement of thalamocortical and corticothalamic latencies.
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Modeling absence seizure dynamics: implications for basic mechanisms and measurement of thalamocortical and corticothalamic latencies.

机译：建模癫痫发作动力学：对丘脑皮质和皮质丘脑潜伏期的基本机制和测量的意义。

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摘要

A successful physiologically based continuum model of the corticothalamic system is applied to determine the relative contributions of axonal and intrinsic cellular delays to the waveforms of absence seizures. The predicted period of the absence seizure depends linearly on model parameters describing thalamocortical, corticothalamic, intracortical, and synaptodendritic delays, and these dependences are linked to the seizure mechanism by showing how time intervals between peaks in the waveforms depend on the parameters. Counterintuitively, it is found that a peak in the local field potential recorded in the thalamic relay nuclei can precede the peak in the cortical field that drove it, without violating causality, but rendering naive interpretation of time intervals between peaks invalid. We argue that a thalamocortical loop mechanism for absence seizures is consistent with intrathalamic cellular properties being the leading determinant of the frequency of spike-wave discharges in rat genetic models, with the combination of network and cellular properties providing a natural explanation for the lower frequency of human absence seizures. Finally, our results imply that the seizure frequency is not determined by the fastest thalamocortical and corticothalamic fibers, but rather depends on an effective weighted conduction velocity of all pathways present.
机译：一个成功的基于生理的连续体模型的皮层丘脑系统被用于确定轴突和固有细胞延迟对失神发作的波形的相对贡献。癫痫发作的预测时间线性依赖于描述丘脑皮质，皮层丘脑，皮质内和突触树突状延迟的模型参数，这些依赖性通过显示波形中峰之间的时间间隔如何依赖于这些参数而与癫痫发作机制相关。与直觉相反，发现丘脑中继核中记录的局部场电势的峰值可以在驱动它的皮质场中的峰值之前，而不会违反因果关系，但是使对峰值之间的时间间隔的幼稚解释无效。我们认为，丘脑皮质环失神发作的机制与丘脑内细胞特性是大鼠遗传模型中尖峰波放电频率的主要决定因素是一致的，网络和细胞特性的结合为低频率的癫痫发作提供了自然的解释。人类失神发作。最后，我们的结果表明，癫痫发作的频率不是由最快的丘脑皮层和皮层丘脑纤维决定的，而是取决于所有通道的有效加权传导速度。

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