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首页> 外文期刊>Journal of Theoretical Biology >Stochastic simulation of actin dynamics reveals the role of annealing and fragmentation.
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Stochastic simulation of actin dynamics reveals the role of annealing and fragmentation.

机译：肌动蛋白动力学的随机模拟揭示了退火和断裂的作用。

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摘要

Recent observations of F-actin dynamics call for theoretical models to interpret and understand the quantitative data. A number of existing models rely on simplifications and do not take into account F-actin fragmentation and annealing. We use Gillespie's algorithm for stochastic simulations of the F-actin dynamics including fragmentation and annealing. The simulations vividly illustrate that fragmentation and annealing have little influence on the shape of the polymerization curve and on nucleotide profiles within filaments but drastically affect the F-actin length distribution, making it exponential. We find that recent surprising measurements of high length diffusivity at the critical concentration cannot be explained by fragmentation and annealing events unless both fragmentation rates and frequency of undetected fragmentation and annealing events are greater than previously thought. The simulations compare well with experimentally measured actin polymerization data and lend additional support to anumber of existing theoretical models.
机译：F-肌动蛋白动力学的最新观察需要理论模型来解释和理解定量数据。许多现有模型都依赖于简化，并且没有考虑F-肌动蛋白片段化和退火。我们使用Gillespie算法对F-肌动蛋白动力学进行随机模拟，包括断裂和退火。模拟生动地表明，片段化和退火对聚合曲线的形状和长丝内的核苷酸谱几乎没有影响，但对F-肌动蛋白长度分布产生了极大影响，使其呈指数级。我们发现，除非断裂速率和未检测到的断裂和退火事件的频率都比以前想象的要大，否则在临界浓度下最近的令人惊讶的高扩散系数测量无法用断裂和退火事件来解释。该模拟与实验测量的肌动蛋白聚合数据进行了很好的比较，并为许多现有的理论模型提供了额外的支持。

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