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首页> 外文期刊>Journal of Theoretical Biology >Theoretical blood glucose control in hyper- and hypoglycemic and exercise scenarios by means of an H(infinity) algorithm.
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Theoretical blood glucose control in hyper- and hypoglycemic and exercise scenarios by means of an H(infinity) algorithm.

机译：通过H（infinity）算法在高血糖和低血糖以及运动场景中进行理论血糖控制。

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摘要

Artificial Endocrine Pancreas (AEP) is one of the most optimistic approaches in Type 1 Diabetes Mellitus (T1DM) treatment due to the novel technological advances in continuous glucose monitoring, exogenous insulin delivery, and their proofs in clinical assessments. The main goal of AEP is to replace the pancreatic insulin secretion in the blood glucose regulation loop by means of an automatic exogenous insulin infusion. The joint element between glucose sensing and insulin delivering actions is an automatic algorithm-based decision. In this contribution, there is an H(infinity) control algorithm to compute the insulin infusion rate during hyperglycemia, exercise and nocturnal hypoglycemia. In order to mimic the insulin release pattern of a healthy pancreas, a frequency restriction in the insulin infusion pattern generated by controller was considered in the design. The inclusion of mathematical models of relations between glucose and chosen biosignals in the control loop generates an adequate insulin infusion pattern to compensate blood glucose variations during each metabolic scenario. The proposed automatic algorithm for decision shows good performance in controlling glycemia in metabolic scenarios, avoiding long-term hyperglycemia as well as glycemic disturbances during exercise and nocturnal hypoglycemia, guaranteeing insulin infusion with a delivery pattern closer to that generated by a healthy pancreas.
机译：人工内分泌胰腺（AEP）是1型糖尿病（T1DM）治疗中最乐观的方法之一，这归因于持续血糖监测，外源胰岛素输送及其临床评估中的新技术进步。 AEP的主要目标是通过自动外源性胰岛素输注来替代血糖调节回路中的胰腺胰岛素分泌。葡萄糖感测和胰岛素递送作用之间的联合要素是基于算法的自动决策。在这种贡献中，有一种H（infinity）控制算法可以计算高血糖，运动和夜间低血糖期间的胰岛素输注速率。为了模拟健康胰腺的胰岛素释放模式，在设计中考虑了控制器产生的胰岛素输注模式的频率限制。在控制回路中包括葡萄糖和所选生物信号之间关系的数学模型会生成适当的胰岛素输注模式，以补偿每种代谢情况下的血糖变化。提出的自动决策算法显示出在代谢情况下控制血糖的良好性能，避免了长期高血糖以及运动和夜间低血糖时的血糖紊乱，从而保证了胰岛素输注的方式与健康胰腺产生的输注方式更接近。

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