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首页> 外文期刊>Journal of toxicology and environmental health, Part A >Integrated disinfection by-products research: assessing reproductive and developmental risks posed by complex disinfection by-product mixtures.
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Integrated disinfection by-products research: assessing reproductive and developmental risks posed by complex disinfection by-product mixtures.

机译：综合消毒副产物研究：评估复杂的消毒副产物混合物对生殖和发育的危害。

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摘要

This article presents a toxicologically-based risk assessment strategy for identifying the individual components or fractions of a complex mixture that are associated with its toxicity. The strategy relies on conventional component-based mixtures risk approaches such as dose addition, response addition, and analyses of interactions. Developmental toxicity data from two drinking-water concentrates containing disinfection by-products (DBP) mixtures were used to illustrate the strategy. The results of this study showed that future studies of DBP concentrates using the Chernoff-Kavlock bioassay need to consider evaluating DBP that are concentrated more than 130-fold and using a rat strain that is more sensitive to chemically-induced pregnancy loss than Sprague-Dawley rats. The results support the planned experimental design of a multigeneration reproductive and developmental study of DBP concentrates. Finally, this article discusses the need for a systematic evaluation of DBP concentrates obtained from multiple source waters and treatment types. The development of such a database could be useful in evaluating whether a specific DBP concentrate is sufficiently similar to tested combinations of source waters and treatment alternatives so that health risks for the former may be estimated using data on the latter.
机译：本文提出了一种基于毒理学的风险评估策略，用于识别与其毒性相关的复杂混合物的各个成分或部分。该策略依赖于常规的基于成分的混合物风险方法，例如剂量添加，响应添加和相互作用分析。使用两种含有消毒副产物（DBP）混合物的饮用水浓缩物的发育毒性数据来说明该策略。这项研究的结果表明，使用Chernoff-Kavlock生物测定法进行DBP浓缩物的进一步研究需要考虑评估浓缩超过130倍的DBP，并使用比Sprague-Dawley对化学诱导的妊娠丢失更敏感的大鼠品系大鼠。结果支持了DBP精矿的多代生殖和发育研究的计划实验设计。最后，本文讨论了对从多种水源和处理类型中获得的DBP浓缩物进行系统评估的必要性。这种数据库的开发对于评估特定的DBP浓缩液是否与来源水和处理替代品的测试组合是否足够相似可能有用，因此可以使用后者的数据估算前者的健康风险。

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