• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of tissue engineering and regenerative medicine >Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications
【24h】

Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications

机译：利用微米和纳米技术开发功能性生物材料，用于组织工程和药物输送应用

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Micro- and nanotechnologies have emerged as potentially effective fabrication tools for addressing the challenges faced in tissue engineering and drug delivery. The ability to control and manipulate polymeric biomaterials at the micron and nanometre scale with these fabrication techniques has allowed for the creation of controlled cellular environments, engineering of functional tissues and development of better drug delivery systems. In tissue engineering, micro- and nanotechnologies have enabled the recapitulation of the micro- and nanoscale detail of the cell's environment through controlling the surface chemistry and topography of materials, generating 3D cellular scaffolds and regulating cell-cell interactions. Furthermore, these technologies have led to advances in high-throughput screening (HTS), enabling rapid and efficient discovery of a library of materials and screening of drugs that induce cell-specific responses. In drug delivery, controlling the size and geometry of drug carriers with micro- and nanotechnologies have allowed for the modulation of parametres such as bioavailability, pharmacodynamics and cell-specific targeting. In this review, we introduce recent developments in micro- and nanoscale engineering of polymeric biomaterials, with an emphasis on lithographic techniques, and present an overview of their applications in tissue engineering, HTS and drug delivery.
机译：微米和纳米技术已经成为潜在有效的制造工具，可以应对组织工程和药物输送面临的挑战。利用这些制造技术来控制和操纵微米级和纳米级聚合物生物材料的能力允许创建受控的细胞环境，设计功能组织并开发更好的药物递送系统。在组织工程中，微技术和纳米技术通过控制材料的表面化学和形貌，生成3D细胞支架并调节细胞与细胞之间的相互作用，使细胞环境的微米和纳米级细节得以概括。此外，这些技术已导致高通量筛选（HTS）的进步，从而能够快速有效地发现材料库并筛选诱导细胞特异性应答的药物。在药物输送中，利用微米和纳米技术控制药物载体的大小和几何形状可以调节参数，例如生物利用度，药效学和细胞特异性靶向。在这篇综述中，我们介绍了聚合物生物材料的微米和纳米级工程学的最新进展，重点是光刻技术，并概述了它们在组织工程学，HTS和药物递送中的应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号