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首页> 外文期刊>Journal of toxicology and environmental health, Part B. Critical reviews >POTENTIAL INPUT FROM METABOLOMICS FOR EXPLORING AND UNDERSTANDING THE LINKS BETWEEN ENVIRONMENT AND HEALTH
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POTENTIAL INPUT FROM METABOLOMICS FOR EXPLORING AND UNDERSTANDING THE LINKS BETWEEN ENVIRONMENT AND HEALTH

机译：从代谢组学中潜在地探索和理解环境与健康之间的联系

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摘要

Humans may be exposed via their environment to multiple chemicals as a consequence of human activities and use of synthetic products. Little knowledge is routinely generated on the hazards of these chemical mixtures. The metabolomic approach is widely used to identify metabolic pathways modified by diseases, drugs, or exposures to toxicants. This review, based on the state of the art of the current applications of metabolomics in environmental health, attempts to determine whether metabolomics might constitute an original approach to the study of associations between multiple, low-dose environmental exposures in humans. Studying the biochemical consequences of complex environmental exposures is a challenge demanding the development of careful experimental and epidemiological designs, in order to take into account possible confounders associated with the high level of interindivid-ual variability induced by different lifestyles. The choices of populations studied, sampling and storage procedures, statistical tools used, and system biology need to be considered. Suggestions for improved experimental and epidemiological designs are described. Evidence indicates that metabolomics may be a powerful tool in environmental health in the identification of both complex exposure biomarkers directly in human populations and modified metabolic pathways, in an attempt to improve understanding the underlying environmental causes of diseases. Nevertheless, the validity of biomarkers and relevancy of animal-to-human extrapolation remain key challenges that need to be properly explored.
机译：由于人类活动和使用合成产品，人类可能会通过环境暴露于多种化学物质中。通常，对这些化学混合物的危害知之甚少。代谢组学方法被广泛用于鉴定被疾病，药物或暴露于毒物而改变的代谢途径。这篇综述基于代谢组学在环境健康中当前应用的最新技术水平，试图确定代谢组学是否可能构成研究人类多种低剂量环境暴露之间关联的原始方法。研究复杂环境暴露的生物化学后果是一个挑战，需要开发仔细的实验​​和流行病学设计，以便考虑到与不同生活方式引起的个体间高水平变异相关的可能混杂因素。需要考虑研究人群的选择，采样和存储程序，使用的统计工具以及系统生物学。描述了改进实验和流行病学设计的建议。有证据表明，代谢组学可能是环境健康中直接识别人群中复杂的暴露生物标志物和修饰的代谢途径的强大工具，以试图增进对疾病的潜在环境原因的认识。然而，生物标志物的有效性以及动物对人类外推的相关性仍然是需要适当探索的关键挑战。

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