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首页> 外文期刊>Journal of toxicology-Clinical toxicology >Prospective observational multi-poison center study of ziprasidone exposures
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Prospective observational multi-poison center study of ziprasidone exposures

机译：齐拉西酮暴露的前瞻性观察性多毒中心研究

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Background. Ziprasidone is an atypical antipsychotic associated witruQTc prolongation during therapeutic use. We characterized the clinical manifestations associated with ziprasidone overdoses, in particular the incidence and severity of QTc prolongation. Methods. Four regional poison centers prospectively collected ziprasidone overdose data from August 1, 2003 to October 1, 2005. Cases were included if they were followed to known medical outcome and comprised single-substance ziprasidone exposures or with co-ingestants not associated with prolongation of the QTc interval. Results. Fifty-six ziprasidone exposures met inclusion criteria. The most common clinical effects were drowsiness (N=38, 67.9%) and tachycardia (N=19, 33.9%). QTc prolongation (>0.500 second) occurred in only one patient. Seven patients had QTc intervals of 0.450 to 0.500 second. Medical outcomes were coded as no effect (13, 23.2%), minor, effect (21, 35.5%), moderate effect (20, 35.7%), or major effect (2, 3.4%). Conclusion. Common clinical effects following ziprasidone overdose are drowsiness and tachycardia. Clinically significant QTc prolongation occurs infrequently.
机译：背景。 Ziprasidone是非典型的抗精神病药相关的witruQTc延长治疗期间。我们表征了与齐拉西酮过量相关的临床表现，特别是QTc延长的发生率和严重性。方法。从2003年8月1日至2005年10月1日，四个区域毒物中心前瞻性地收集了齐拉西酮过量的数据。如果病例遵循已知的医疗结果并且包括单物质齐拉西酮的暴露或与QTc延长无关的辅食者，则包括这些病例。间隔。结果。五十六次齐拉西酮暴露符合纳入标准。最常见的临床效果是嗜睡（N = 38，67.9％）和心动过速（N = 19，33.9％）。仅一名患者发生QTc延长（> 0.500秒）。 7名患者的QTc间隔为0.450至0.500秒。医学结果编码为无效果（13，23.2％），轻微，有效（21，35.5％），中度效果（20，35.7％）或主要效果（2，3.4％）。结论。过量服用齐拉西酮后的常见临床效果是嗜睡和心动过速。临床上显着的QTc延长很少发生。

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