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首页> 外文期刊>Journal of toxicology-Clinical toxicology >Urinary serotonin level is associated with serotonin syndrome after moclobemide, sertraline, and citalopram overdose
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Urinary serotonin level is associated with serotonin syndrome after moclobemide, sertraline, and citalopram overdose

机译：莫洛贝比德，舍曲林和西酞普兰过量后尿中5-羟色胺水平与5-羟色胺综合征相关

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Introduction. Altered mental status, autonomic dysfunction, and neuromuscular abnormalities are a characteristic triad of serotonin syndrome. No laboratory tests confirm the diagnosis of serotonin syndrome. Case report. A 35-year-old woman took moclobemide, sertraline, and citalopram in a suicide attempt. She was conscious with mild tachycardia, hypertension, and tachypnea one hour after ingestion. In the second hour after ingestion diaphoresis, mydriasis, horizontal nystagmus, trismus, hyperreflexia, clonus, and tremor appeared. She became agitated and unresponsive. In the third hour after ingestion she became comatose and hyperthermic. She was anesthetized, paralyzed, intubated, and ventilated for 24 hours. Serum moclobemide, sertraline, and citalopram levels were above therapeutic levels. The serum serotonin level was within normal limits and the urinary 5-hydroxyindoleacetic acidxreatinine ratio was below the average daily value. The urinary serotoninxreatinine ratio was increased on arrival (1 mg/g). Discussion and conclusion. The urinary serotonin level is increased in serotonin syndrome due to a monoamine oxidase inhibitor and selective serotonin-reuptake inhibitors overdose. It is possible that urinary serotonin concentration could be used as a biochemical marker of serotonin syndrome.
机译：介绍。精神状态改变，植物神经功能紊乱和神经肌肉异常是5-羟色胺综合征的特征性三联征。没有实验室测试可以确定5-羟色胺综合征的诊断。案例报告。一名35岁的妇女自杀未遂，服用了吗氯贝胺，舍曲林和西酞普兰。摄入后一小时，她意识到患有轻度心动过速，高血压和呼吸急促。摄食性出汗后第二小时，出现瞳孔散大，水平眼球震颤，三头肌，反射亢进，阵挛和震颤。她变得烦躁不安。摄入后的第三小时，她昏迷了，体温过高。她被麻醉，瘫痪，插管和通气24小时。血清氯丁苯胺，舍曲林和西酞普兰的水平高于治疗水平。血清5-羟色胺水平在正常范围之内，尿中5-羟吲哚乙酸xreatinine比值低于每日平均值。到达时尿中5-羟色胺素含量增加（1 mg / g）。讨论和结论。在血清素综合征中，由于单胺氧化酶抑制剂和选择性5-羟色胺再摄取抑制剂过量导致尿中5-羟色胺水平升高。尿中5-羟色胺的浓度可以用作5-羟色胺综合征的生化指标。

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