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首页> 外文期刊>Journal of toxicology-Clinical toxicology >Data collection in clinical toxinology: debunking myths and developing diagnostic algorithms.
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Data collection in clinical toxinology: debunking myths and developing diagnostic algorithms.

机译：临床毒素学中的数据收集：揭穿神话并开发诊断算法。

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Clinical toxinology suffers from a long history of poor data collection. A 20-year review of MEDLINE illustrates the lack of randomized controlled trials and prospective studies in clinical toxinology. Mythology surrounds bites and stings, resulting from the general fear of many creatures such as spiders, which has not been disproved by appropriate well-designed studies. The current focus on necrotic arachnidism in many parts of the world is a good example. Previously, most studies have been retrospective, bites and stings have not been confirmed, and creatures have not been kept or have been incorrectly identified. Prospective observational studies of confirmed bites with correct identification of the creature are required in clinical toxinology. This requires a collaboration between those who can correctly identify the animals (biologists/taxonomists) and those involved in the clinical management (poison information services, emergency departments, and toxicology services). Prospective collection of data pertaining to the circumstances and effects of the bites is essential. Routine follow-up is required to identify delayed effects and the duration of immediate effects. Analysis of databases created from prospective studies will not only answer questions about the effects of different species, but will ultimately allow the development of evidence-based methods to identify animals based on the circumstances and effects of bites, rather than requiring formal identification of the culprit.
机译：临床毒素学长期遭受不良数据收集的困扰。对MEDLINE进行的20年回顾表明，在临床毒素学方面缺乏随机对照试验和前瞻性研究。神话围绕着叮咬和st伤，这是由于人们对许多生物（例如蜘蛛）的普遍恐惧所致，而没有经过适当设计周密的研究来证明这一点。当前在世界许多地方对坏死性蜘蛛网的关注是一个很好的例子。以前，大多数研究都是回顾性的，咬伤和st伤尚未得到确认，生物没有被保留或被错误识别。临床毒素学要求对经过确认的叮咬进行正确的生物识别的前瞻性观察研究。这就要求能够正确识别动物的人（生物学家/分类学家）与参与临床管理的人（毒物信息服务，急诊科和毒理学服务）之间进行合作。预先收集有关被咬情况和影响的数据至关重要。需要定期随访以确定延迟的影响和即时影响的持续时间。对由前瞻性研究创建的数据库进行的分析不仅将回答有关不同物种的影响的问题，而且最终将允许开发基于证据的方法来根据叮咬的情况和影响来识别动物，而无需正式识别罪魁祸首。

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