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首页> 外文期刊>Journal of Trace Elements in Experimental Medicine >Role of Vitamins in Treatment of Lead Intoxication
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Role of Vitamins in Treatment of Lead Intoxication

机译：维生素在铅中毒治疗中的作用

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The efficacy of thiamine, ascorbic acid, and becozinc (a pharmacological preparation containing vitamins of the B-complex group, vitamin C, and zinc) in enhancing excretion and reducing tissue burden of lead and reversing lead-sensitive biochemical alterations was investigated in lead pre-exposed rat. These vitamins were effective in mobilizing lead from blood, liver, and kidney into urine and/or feces and in restoring partially blood zinc pro-toporphyrin level. All the vitamins were effective in reversing completely the lead-induced increase in blood and renal calcium levels, and becozinc was particularly effective in restoring the decreased hepatic and tibia zinc content. However, the inhibition of blood 8-aminolevulinic acid dehydratase activity and increase in urinary aminolevulinic acid excretion due to lead remained uninfluenced, which may require more time for recovery. The results suggest the use of becozinc as a safe alternate to treatment of lead poisoning with the chelating agents.
机译：在铅制铅前研究了硫胺素，抗坏血酸和becozinc（一种含有B-复合物组维生素，维生素C和锌的药物制剂）在促进排泄，减轻铅的组织负担以及逆转铅敏感性生化改变方面的功效。暴露的老鼠。这些维生素可有效地将血液，肝脏和肾脏中的铅动员到尿液和/或粪便中，并能部分恢复血液中原卟啉锌的水平。所有的维生素都可以有效地完全逆转铅引起的血液和肾脏钙水平的升高，而贝考锌对恢复肝脏和胫骨锌含量的减少特别有效。但是，对血液中8-氨基乙酰丙酸脱水酶活性的抑制和铅引起的尿中氨基乙酰丙酸排泄的增加仍然没有受到影响，这可能需要更多的恢复时间。结果表明使用becozinc作为使用螯合剂治疗铅中毒的安全替代方法。

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