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首页> 外文期刊>Journal of Trace Elements in Experimental Medicine >Iron: Seminal Publications of the Twentieth Century-Haemochromatosis
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Iron: Seminal Publications of the Twentieth Century-Haemochromatosis

机译：铁：20世纪的开创性出版物-血色素沉着病

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摘要

Iron is vital for all living organisms because it is essential for metabolic processes to include oxygen transport; DNA synthesis and electron transport. Removal of iron from tissue culture media causes a prompt cessation of cellular metabolic function and cell division.In the primordial anaerobic world iron was ferrous. Primitive organisms utilize simple iron proteins such as the iron-sulfur proteins. With the development of an aerobic world iron metabolism became more complex. Most iron was oxidized to the ferric state and ferric iron is insoluble above pH 2. Organisms developed more sophisticated mechanisms that kept iron soluble at pnysiological pH and facilitated the transport of iron for vital biological functions while preventing the availability of ionic iron that could produce "free radical" damage to tissues. These functions were facilitated by transferrin and ferritin and a host of other newly discovered iron binding proteins.
机译：铁对所有生物都是至关重要的，因为它对于新陈代谢过程中包括氧气运输至关重要。 DNA合成和电子传输。从组织培养基中去除铁会导致细胞代谢功能和细胞分裂迅速停止。在原始厌氧世界中，铁是亚铁。原始生物利用简单的铁蛋白，例如铁硫蛋白。随着世界有氧运动的发展，铁的代谢变得越来越复杂。大多数铁被氧化成三价铁，而三价铁在pH高于2时不溶。生物体开发出更为复杂的机制，使铁保持在药理pH值下可溶，并促进了铁的转运以实现重要的生物学功能，同时阻止了可产生“自由基”对组织的损害。转铁蛋白和铁蛋白以及许多其他新发现的铁结合蛋白促进了这些功能。

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