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首页> 外文期刊>Journal of Trace Elements in Experimental Medicine >Importance of the Report 'Syndrome of Iron Deficiency Anemia, Hepatosplenomegaly, Hypogonadism, Dwarfism and Geophagia'
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Importance of the Report 'Syndrome of Iron Deficiency Anemia, Hepatosplenomegaly, Hypogonadism, Dwarfism and Geophagia'

机译：报告“缺铁性贫血，肝脾肿大，性腺机能减退，侏儒症和吞噬症的综合症”的重要性

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This commentary will focus on clinical research for which Prasad et al. [1] is a plausible progenitor. My assessment is personal because I participated in the studies conducted in Egypt that tested Prasad's hypothesis.When Ananda Prasad [1,2] discussed a patient at the-medical-grand-rounds of the Saadi Hospital, Shiraz, Iran in 1958, at the invitation of James Halsted, he was presented a 21-year old farmer with weakness, easy fatigability, dyspnea, and palpitation of ten years' duration. For four years he had been unable to work, was pale, and had frequent nocturnal "fever." He had always been small and sexually underdeveloped. Since childhood had practiced geophagia. His diet had consisted mainly of village bread prepared from wheat, milk, and potatoes. He rarely ate meat of any kind, eggs, or vegetables. He had two living brothers and two sisters, who as far as he knew were well. A sister, age 18 years, had died with edema and jaundice. Two sisters died in early childhood. A third brother, aged 22 years, was short, sexually underdeveloped, had malformed extremities, was mentally retarded and practiced geophagia.The patient's vital signs were pulse 100/minute, blood pressure 105/55 mm Hg, temperature 37.4°C, height 135 cm and weight 29.5 kg. Acral, perioral, perineal, or other regional hyperkeratosis, other dermatitis, cheilosis or angular oral fissures were not described. He was pale and had koilonychia. His genitalia were infantile and secondary sexual development was absent. His liver and spleen were palpable 4 cm below the costal margin.
机译：这篇评论将集中于Prasad等人的临床研究。 [1]是合理的祖细胞。我的评估是个人的，因为我参加了在埃及进行的检验普拉萨德假说的研究。当阿南达·普拉萨德[1,2]于1958年在伊朗设拉子的萨阿迪医院的医疗大队中讨论一名患者时，应詹姆斯·霍尔斯泰德（James Halsted）的邀请，他被授予一名21岁的农夫，身体虚弱，容易疲劳，呼吸困难且心pa十年。四年来，他一直无法工作，面色苍白，并且经常出现夜间“发烧”。他一直很小，性发育不佳。从小就开始从事吞噬。他的饮食主要包括用小麦，牛奶和土豆制成的乡村面包。他很少吃任何肉，鸡蛋或蔬菜。据他所知，他有两个活着的兄弟和两个姐妹。一个18岁的姐姐死于水肿和黄疸。两姐妹在儿童早期死亡。第三名哥哥，年龄22岁，矮小，性发育不全，四肢畸形，智力低下并患有吞咽痛。患者的生命体征为脉搏100 /分钟，血压105/55 mm Hg，温度37.4°C，身高135厘米和体重29.5公斤。未描述髋臼，口周，会阴或其他区域性角化过度，其他皮炎，唇疱病或口腔角裂。他脸色苍白，患有肺泡炎。他的生殖器是婴儿，没有继发性发育。他的肝脏和脾脏位于肋缘以下4 cm处。

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