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首页> 外文期刊>Journal of Toxicology-Toxin Reviews >MONOMERIC AND DIMERIC DISINTEGRINS: PLATELET ACTIVE AGENTS FROM VIPER VENOM
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MONOMERIC AND DIMERIC DISINTEGRINS: PLATELET ACTIVE AGENTS FROM VIPER VENOM

机译：单体和二元分解素：VIPER VENOM的血小板活性剂

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摘要

When the term "disintegrin" was first coined in 1990, it described a family of naturally occurring proteins with low molecular weights and highly conserved sequences, both in their cysteine arrangements and adhesive Arg-Gly-Asp (RGD) motifs. Another common characteristic was the inhibitory potential these proteins demonstrated in interacting with cell-surface integrin receptors. Measurement of the effect by disintegrins on the interaction between the platelet receptor alphaIIbbeta3 and its ligand, fibrinogen, has become a hallmark assay for comparing the activities of members of this increasingly diverse family discovered in the past two decades. This review focuses on the inhibitory profiles, based on platelet function, of the monomeric and heterodimeric disintegrins described to date, as well as the informative contributions of disintegrin mutations in our understanding of the structure-function relationships between ligand and alphaIIbbeta3. The challenge of naming future examples of these proteins is also addressed.
机译：1990年，当“ disintegrin”一词首次出现时，它描述了一个自然存在的蛋白质家族，其半胱氨酸排列形式和粘附的Arg-Gly-Asp（RGD）图案均具有低分子量和高度保守的序列。另一个共同的特征是这些蛋白质在与细胞表面整联蛋白受体相互作用中表现出抑制潜力。通过整联蛋白对血小板受体αIIbbeta3及其配体纤维蛋白原之间相互作用的影响进行测量已成为比较过去二十年来发现的这个日益多样化的家族成员的活性的标志性检测方法。这篇综述着重于迄今为止描述的基于血小板功能的单体和异二聚体整合素的抑制特性，以及整合素突变在我们对配体与αIIbbeta3之间的结构-功能关系的理解中的有益贡献。还解决了命名这些蛋白质的未来实例的挑战。

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