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首页> 外文期刊>Journal of Veterinary Diagnostic Investigation >Association between Mycobacterium avium subsp. paratuberculosis infection among offspring and their dams in nondomestic ruminant species housed in a zoo
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Association between Mycobacterium avium subsp. paratuberculosis infection among offspring and their dams in nondomestic ruminant species housed in a zoo

机译：禽分枝杆菌亚种之间的关联。动物园内非家养反刍动物的后代及其大坝之间的副结核病感染

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The objective of the present study was to determine whether offspring of dams infected with Mycobacterium avium subsp. paratuberculosis (Map) have an increased risk for Map infection. Antemortem and postmortem disease surveillance data were used toidentify positive and test-negative ruminants born at the Zoological Society of San Diego (ZSSD) between 1991 and 2007 and to estimate cumulative lifetime incidence. A matched case-control study, nested within the population, was conducted and conditional logistic regression analyses were used to quantify the association between infection status of offspring and their dams. Cases (infected ruminants, n = 47) were matched to controls (test-negative ruminants, n = 152) by species, birth date, birth enclosure, and follow-up time to control for confounding factors. The overall cumulative lifetime incidence of infection was estimated at 2.2%, but it decreased over time and varied by species. There was a significant association between infection status of offspring and their dams (odds ratio [OR] = 6.8, P < 0.01), which is consistent with studies in domestic livestock species. The association was stronger for animals whose dam was diagnosed within 2 years of their birth (OR = 9.0, P < 0.01) than for animalswhose dam was diagnosed more than 2 years after their birth (OR = 6.0, P < 0.01) compared to animals with test-negative dams. For positive animals born to a positive dam, 85.3% of the Map infections were attributable to having a positive dam. For the entire population of ZSSD ruminants, 36.8% of the cases were attributable to having a positive dam. Findings will help guide future management of Map infection in zoo ruminant populations.
机译：本研究的目的是确定是否感染了鸟分枝杆菌亚种的水坝后代。副结核病（地图）患地图感染的风险增加。使用死前和死后疾病监测数据来鉴定1991年至2007年之间在圣地亚哥动物学协会（ZSSD）出生的反刍动物的阳性和阴性。进行了一个匹配的病例对照研究，该研究嵌套在种群中，并使用条件逻辑回归分析来量化后代与其大坝的感染状况之间的关联。病例（感染的反刍动物，n = 47）与对照（测试阴性的反刍动物，n = 152）按物种，出生日期，出生围栏和随访时间进行对照，以控制混杂因素。终生感染的总体累积发生率估计为2.2％，但随着时间的推移而下降，并且因物种而异。后代与母鼠的感染状况之间存在显着关联（优势比[OR] = 6.8，P <0.01），这与对家畜的研究一致。与动物相比，在出生后两年内被诊断为大坝的动物（OR = 9.0，P <0.01）的关联性强于在出生后两年以上被诊断为大坝的动物（OR = 6.0，P <0.01）的关联性与测试阴性水坝。对于阳性水坝出生的阳性动物，Map感染的85.3％可归因于阳性水坝。在整个ZSSD反刍动物种群中，有36.8％的病例归因于阳性大坝。这些发现将有助于指导动物园反刍动物种群中Map感染的未来管理。

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