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首页> 外文期刊>Journal of Veterinary Research >Parapoxvirus orf virus infection induces an increase in interleukin-8, tumour necrosis factor-alpha, and decorin in goat skin fibroblast cells
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Parapoxvirus orf virus infection induces an increase in interleukin-8, tumour necrosis factor-alpha, and decorin in goat skin fibroblast cells

机译：副痘病毒orf病毒感染导致山羊皮肤成纤维细胞中白介素8，肿瘤坏死因子-α和除胶蛋白增加

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Introduction: Orf virus (ORFV) is a prototype Parapoxvirus species in the Poxviridae family that causes serious zoonotic infectious disease. Goat skin fibroblast (GSF) cells are the major host targets of ORFV. Interleukin 8 (IL-8) and tumour necrosis factor (TNF)-alpha are known to play a vital role in immune response during viral infections. However, the manner of variation over time of their level of expression in GSF cells remains unclear. Material and Methods: In this study, quantitative enzyme-linked immunosorbent assay chips were used to detect changes in the levels of these cytokines expressed and secreted in GSF cells after ORFV infection. Results: Results showed that the expression of IL-8, TNF-alpha, and decorin was upregulated in the cell lysates, and that secreted decorin and IL-8 were significantly increased in cell supernatant. Conclusion: The results provided possible approaches to elucidation of how ORFV infection initiates host cell immune response.
机译：简介：Orf病毒（ORFV）是Poxviridae家族中的一种原型副痘病毒，可引起严重的人畜共患传染病。山羊皮肤成纤维细胞（GSF）细胞是ORFV的主要宿主目标。已知白介素8（IL-8）和肿瘤坏死因子（TNF）-α在病毒感染期间的免疫反应中起着至关重要的作用。但是，尚不清楚它们在GSF细胞中表达水平随时间变化的方式。材料和方法：在这项研究中，定量酶联免疫吸附测定芯片用于检测ORFV感染后GSF细胞表达和分泌的这些细胞因子水平的变化。结果：结果表明，细胞裂解物中IL-8，TNF-α和decorin的表达上调，并且细胞上清液中decorin和IL-8的分泌显着增加。结论：该结果为阐明ORFV感染如何引发宿主细胞免疫反应提供了可能的方法。

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