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首页> 外文期刊>Journal of Veterinary Pharmacology and Therapeutics >Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)
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Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)

机译:阿片类药物在Speke铰链乌龟(Kinixy's spekii)中的福尔马林测试中的作用

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摘要

Little is known about analgesia in lower vertebrates such as the Speke's hinged tortoise (Kinixy's spekii), yet of late they are increasingly being adopted as pets. The effects of morphine (5, 7.5, 10 and 20 mg/kg), pethidine (10, 20, and 50 mg/kg) and naloxone (5 mg/kg) on nociception induced by the formalin test (12.5%, 100 mu L) were studied in the Speke's hinged tortoise. Formalin induced a monophasic limb retraction behavioural response and its duration was recorded. The behaviour lasted for 16.4 +/- 0.8 min. Morphine (7.5, 10 and 20 mg/kg) and pethidine (20 and 50 mg/kg) induced significant decrease in the duration of limb retraction in the formalin test. The anti-nociceptive effects were naloxone (5 mg/kg) reversible. The data suggest that the formalin test is a good test for studying nociception and anti-nociception in tortoises and that the opioidergic system plays a role in the control of nociception in these animals.
机译:人们对诸如Speke铰链乌龟(Kinixy的spekii)等下层脊椎动物的镇痛知之甚少,但近来它们被越来越多地用作宠物。吗啡(5、7.5、10和20 mg / kg),哌替啶(10、20和50 mg / kg)和纳洛酮(5 mg / kg)对福尔马林试验引起的伤害感受的影响(12.5%,100 mu L)在Speke的乌龟上进行了研究。福尔马林诱导单相肢体回缩行为反应并记录其持续时间。该行为持续了16.4 +/- 0.8分钟。在福尔马林测试中,吗啡(7.5、10和20 mg / kg)和哌替啶(20和50 mg / kg)引起四肢缩回持续时间的显着减少。抗伤害感受性是可逆的纳洛酮(5 mg / kg)。数据表明,福尔马林测试是研究陆龟伤害感受和抗伤害感受的很好的测试方法,而视皮醇功能系统在控制这些动物的伤害感受中起着重要作用。

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