...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of tropical pediatrics. >Disease progression markers during asymptomatic phase of HIV-1 infected children with unimpaired CD4+ cell values: evaluation of repeat CD4+ cell evaluation vs. other immunological parameters.
【24h】

Disease progression markers during asymptomatic phase of HIV-1 infected children with unimpaired CD4+ cell values: evaluation of repeat CD4+ cell evaluation vs. other immunological parameters.

机译：HIV-1感染儿童的CD4 +细胞值未受损的无症状阶段的疾病进展标记：重复CD4 +细胞评估与其他免疫学参数的评估。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The availability of a marker that could predict the course of disease progression in HIV-infected individuals would be of considerable relevance during the asymptomatic stage in order to undertake timely prophylactic measures. A prospective study was undertaken in a group of 42 children suffering from thalassemia major with HIV-1 infection to assess the status of immune parameters, such as peripheral CD4+ T lymphocyte (CD4+ cell) percentage, delayed type of hypersensitivity (DTH) response to recall antigens, detection rate and levels of p24 antigen, and levels of beta-2 microglobulin and cytokines in serum. All were assessed at an interval of 2 years during the asymptomatic period, (baseline and follow-up assessments) in relation to the development of AIDS defining illness within a follow-up period of 3 years. No difference could be observed in the mean CD4+ cell percentage at baseline between those who progressed subsequently to develop AIDS within the follow-up period (progressors) and those who did not (non-progressors). However, at the point of follow-up assessment the progressor group showed significantly lower CD4+ cell percentage compared to the non-progressor group (33 +/- 4.9 vs. 22 +/- 5.6; p < 0.05), although in the progressor group there was no correlation of the baseline and follow-up CD4+ cell percentage with the duration of the AIDS-free interval. However, in the progressor group there was a strong negative correlation between the rate of decline in CD4+ cell percentage and subsequent duration of the AIDS-free interval (r = -0.859). Analysis of additional immune parameters at baseline revealed that the progressor group, despite having CD4+ cell values comparable to non-progressors, showed impaired DTH response (number and total induration of positive responses being 2.0 +/- 1.23 and 6.2 +/- 1.4 in the former group vs. 3.2 +/- 0.76 and 12.6 +/- 3.80 in the later group; p < 0.05 for both the parameters), and elevated levels (mg/l) of serum beta-2 microglobulin (2.92 +/- 0.89 vs. 1.38 +/- 0.43;p < 0.05). The serum cytokine profile at baseline in the progressor group showed a T helper type-2 (Th2) dominant pattern, i.e. elevation of interleukin-4 (IL-4) and interleukin-10 (IL-10) levels with decreased levels of interleukin-2 (IL-2) and gamma interferon (gamma-IFN) compared to the non-progressor group that showed a T helper type-1 (Th1) dominant profile, i.e., elevation of IL-1 and gamma-IFN level with decreased levels of IL-4 and IL-10 (p < 0.05 for all four cytokines). The present study points out that rate of decline rather than single point of assessment of CD4+ cell values is a more reliable predictor for disease progression in HIV-1 infected children. In addition, parameters such as DTH response, serum levels of beta-2 microglobulin and serum cytokine profile, may provide valuable predictors of subsequent fall in CD4+ cell value.
机译：为了能够及时采取预防措施，在无症状阶段可以使用可预测HIV感染者疾病进展过程的标记物具有重大意义。对一组42名患有重型地中海贫血的HIV-1感染儿童进行了一项前瞻性研究，以评估免疫参数的状况，例如外周CD4 + T淋巴细胞（CD4 +细胞）百分比，对召回的迟发型超敏反应（DTH）类型抗原，p24抗原的检出率和水平以及血清中β-2微球蛋白和细胞因子的水平。在无症状期间，每隔2年对所有患者进行一次评估（基线和随访评估），以跟进3年随访期内艾滋病定义疾病的发展。在随访期内随后进展为患艾滋病的患者（进展者）与未进展者（非进展者）在基线时的平均CD4 +细胞百分比上没有观察到差异。但是，在随访评估时，进展者组的CD4 +细胞百分比显着低于非进展者组（33 +/- 4.9对22 +/- 5.6; p <0.05），尽管在进展者组中基线和后续CD4 +细胞百分比与无AIDS间隔的持续时间没有相关性。但是，在进展组中，CD4 +细胞百分比的下降速率与随后的无艾滋病间隔时间之间存在强烈的负相关性（r = -0.859）。在基线时对其他免疫参数的分析显示，尽管进展者组的CD4 +细胞值与非进展者相当，但显示DTH反应受损（阳性反应的数量和总硬结度分别为2.0 +/- 1.23和6.2 +/- 1.4。前一组与后一组的分别为3.2 +/- 0.76和12.6 +/- 3.80;两个参数的p <0.05）和血清β-2微球蛋白水平（mg / l）升高（2.92 +/- 0.89 vs 1.38 +/- 0.43; p <0.05）。进展者组在基线时的血清细胞因子谱显示为T型辅助2型（Th2）显性模式，即白介素4（IL-4）和白介素10（IL-10）水平升高，白介素2（IL-2）和γ干扰素（γ-IFN）与非进展组比较，后者显示T型辅助1型（Th1）占主导地位，即IL-1和γ-IFN水平升高且水平降低IL-4和IL-10的浓度（所有四种细胞因子的p均<0.05）。本研究指出，CD4 +细胞值的下降速率而非单点评估是HIV-1感染儿童疾病进展的更可靠预测指标。另外，诸如DTH反应，β-2微球蛋白的血清水平和血清细胞因子谱等参数可以为CD4 +细胞值随后下降提供有价值的预测指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号