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首页> 外文期刊>Journal of wildlife diseases >Fatal herpesvirus hemorrhagic disease in wild and orphan Asian elephants in Southern India.
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Fatal herpesvirus hemorrhagic disease in wild and orphan Asian elephants in Southern India.

机译：印度南部野生和孤立的亚洲象中的致命疱疹病毒出血性疾病。

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摘要

Up to 65% of deaths of young Asian elephants (Elephas maximus) between 3 mo and 15 yr of age in Europe and North America over the past 20 yr have been attributed to hemorrhagic disease associated with a novel DNA virus called elephant endotheliotropic herpesvirus (EEHV). To evaluate the potential role of EEHV in suspected cases of a similar lethal acute hemorrhagic disease occurring in southern India, we studied pathologic tissue samples collected from field necropsies. Nine cases among both orphaned camp and wild Asian elephants were identified by diagnostic PCR. These were subjected to detailed gene subtype DNA sequencing at multiple PCR loci, which revealed seven distinct strains of EEHV1A and one of EEHV1B. Two orphan calves that died within 3 days of one another at the same training camp had identical EEHV1A DNA sequences, indicating a common epidemiologic source. However, the high level of EEHV1 subtype genetic diversity found among the other Indian strains matches that among over 30 EEHV1 strains that have been evaluated from Europe and North America. These results argue against the previous suggestions that this is just a disease of captive elephants and that the EEHV1 virus has crossed recently from African elephant (Loxodonta africana) hosts to Asian elephants. Instead, both the virus and the disease are evidently widespread in Asia and, despite the disease severity, Asian elephants appear to be the ancient endogenous hosts of both EEHV1A and EEHV1B.
机译：在过去的20年中，欧洲和北美在3个月至15岁之间的亚洲象（Elephas maximus）年龄中，在过去20年中，多达65％的死亡归因于出血性疾病，该疾病与一种称为大象内吸性疱疹病毒的新型DNA病毒有关）。为了评估EEHV在印度南部发生的类似致命急性出血性疾病的疑似病例中的潜在作用，我们研究了从现场尸检中收集的病理组织样本。通过诊断PCR在孤儿营地和亚洲野生象中发现了9例。在多个PCR位点对它们进行了详细的基因亚型DNA测序，揭示了7个不同的EEHV1A菌株和1个EEHV1B菌株。在同一训练营中彼此死亡三天之内死亡的两只孤牛具有相同的EEHV1A DNA序列，表明是共同的流行病学来源。但是，在其他印度菌株中发现的高水平的EEHV1亚型遗传多样性与已经从欧洲和北美进行评估的30多个EEHV1菌株中的高。这些结果违背了先前的建议，即这仅是圈养大象的一种疾病，并且EEHV1病毒最近已从非洲象（非洲象）的宿主传播到亚洲象。相反，病毒和疾病显然都在亚洲广泛传播，尽管疾病严重，但亚洲象似乎是EEHV1A和EEHV1B的古老内源宿主。

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