• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of vascular research >Adhesion molecule expression in postischemic microvascular dysfunction: activity of a micronized purified flavonoid fraction.
【24h】

Adhesion molecule expression in postischemic microvascular dysfunction: activity of a micronized purified flavonoid fraction.

机译：缺血后微血管功能障碍中的黏附分子表达：微粉化纯化黄酮类化合物的活性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ischemia and reperfusion (I/R) induces neutrophil infiltration in skeletal muscle that is localized to the ischemic region. To transmigrate at ischemic regions, granulocytes must first arrest in the postcapillary venular segment of the microcirculation. Initially, leukocytes roll along the endothelium of these venules, a weak adhesive interaction that is mediated by the selectins (L-, E-, and P-selectin). Leukocyte rolling functions to slow the neutrophil during its transit through the microcirculation, thereby allowing it to monitor its local environment for the presence of activating factors arising from the ischemic tissues. When activated, the rolling granulocyte is rendered capable of forming the stronger adhesive interactions that allow the cell to become arrested in postcapillary venules in the ischemic region. These adhesive interactions are mediated by a leukocyte glycoprotein complex designated CD11/CD18 and intercellular adhesion molecule-1 (ICAM-1) expressed on endothelial cells. The stationary neutrophil uses the gradient in concentration of soluble chemoattractants liberated from ischemic tissues as a directional cue to move from the vascular to extravascular compartment, being guided in its transit across the endothelium by interactions with platelet endothelial cell adhesion molecule-1 (PECAM-1), an adhesive molecule localized to the interendothelial cleft. This paper reviews current understanding of the mechanisms underlying the establishment of leukocyte/endothelial cell interactions in postischemic skeletal muscle in terms of specific adhesion molecules that participate in neutrophil sequestration after I/R. Discovery of the molecular determinants of neutrophil/endothelial cell adhesion has uncovered potential mechanisms whereby agents exhibiting anti-adhesive properties may act. The micronized purified flavonoid fraction (450 mg diosmin, 50 mg hesperidin) prevents I/R-induced leukocyte adhesion in skeletal muscle. This anti-adhesive effect appears to be mediated at least in part by inhibition of induced expression of ICAM-1.
机译：缺血和再灌注（I / R）会在局部位于局部缺血区域的骨骼肌中诱导中性粒细胞浸润。为了在局部缺血区域迁移，粒细胞必须首先停滞在微循环的毛细血管后静脉段。最初，白细胞沿这些小静脉的内皮滚动，这是由选择素（L-，E-和P-选择素）介导的弱粘附相互作用。白细胞滚动的功能是在中性粒细胞通过微循环的过程中减慢其速度，从而使其能够监测其局部环境中是否存在由缺血性组织引起的活化因子。当被激活时，滚动的粒细胞就能够形成更强的粘附相互作用，从而使细胞停滞在缺血区域的毛细血管后小静脉中。这些粘附相互作用是由称为CD11 / CD18的白细胞糖蛋白复合物和在内皮细胞上表达的细胞间粘附分子1（ICAM-1）介导的。静止的中性粒细胞利用从缺血组织中释放出来的可溶性趋化剂浓度梯度作为从血管向血管外腔室移动的方向提示，并通过与血小板内皮细胞粘附分子-1（PECAM-1）的相互作用引导其穿过内皮的转运。 ），黏附分子位于内皮间隙。本文根据参与I / R后中性粒细胞隔离的特异性粘附分子，综述了对缺血后骨骼肌中白细胞/内皮细胞相互作用建立基础的机制的当前理解。中性粒细胞/内皮细胞粘附分子决定因素的发现已经揭示了潜在的机制，据此，具有抗粘附特性的药物可能起作用。微粉化的纯化黄酮类成分（450 mg薯os，50 mg橙皮苷）可防止I / R诱导的骨骼肌白细胞粘附。这种抗粘连作用似乎至少部分地通过抑制ICAM-1的诱导表达来介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号