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首页> 外文期刊>Journal of vascular research >Effect of elastin peptides on vascular tone.
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Effect of elastin peptides on vascular tone.

机译：弹性蛋白肽对血管紧张度的影响。

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Elastin peptides are present in human blood. As elastin receptors exist on several cell types, especially endothelial cells, this investigation was carried out to study the effect of elastin peptides on vascular tone. For this purpose, rat aortic rings were mounted in an organ bath for isometric tension measurements. Elastin peptides (kappa-elastin) were added in the concentration range of 0.1 ng/ml to 1 microgram/ml, concentrations similar to those found in the circulating blood. In rat aortic rings, precontracted or not with noradrenaline (10(-6) M), elastin peptides induced an endothelium-dependent vasodilation. The pretreatment of aortic rings with N-omega-nitro-L-arginine methyl ester (10(-5) M), an inhibitor of nitric oxide (NO) production, or with indomethacin (10(-5) M), an inhibitor of cyclooxygenase, prevented elastin peptide-induced vasodilation. These findings suggest that elastin peptides act through the synthesis of prostanoids, leading to the production of NO. Moreover, this relaxant effect of elastin peptides was decreased or inhibited when aortic rings were treated with lactose (10(-5) to 10(-2) M) or laminin (10(-6) to 10(-4) mg/ml) whereas lactose or laminin was unable to inhibit acetylcholine-induced vasodilation. These findings suggest that the inhibitory effects of lactose and laminin are specific for elastin peptide receptors and are in agreement with previous studies on these receptors. As there is evidence of the degradation of elastin in several vascular diseases, the concept that elastin peptides may contribute to the control of vascular tone is discussed.
机译：弹性蛋白肽存在于人血中。由于弹性蛋白受体存在于几种细胞类型，特别是内皮细胞上，因此进行了这项研究以研究弹性蛋白肽对血管紧张度的影响。为此，将大鼠主动脉环安装在器官浴中以进行等轴测张力。弹性蛋白肽（κ-弹性蛋白）的添加浓度范围为0.1 ng / ml至1微克/ ml，其浓度与循环血液中的浓度相似。在大鼠主动脉环中，无论是否与去甲肾上腺素（10（-6）M）预收缩，弹性蛋白肽均可诱导内皮依赖性血管舒张。用一氧化氮（NO）生成抑制剂N-ω-硝基-L-精氨酸甲酯（10（-5）M）或抑制剂吲哚美辛（10（-5）M）预处理主动脉环环氧合酶的作用，防止弹性蛋白肽诱导的血管舒张。这些发现表明，弹性蛋白肽通过类前列腺素的合成起作用，从而导致NO的产生。此外，当用乳糖（10（-5）至10（-2）M）或层粘连蛋白（10（-6）至10（-4）mg / ml处理主动脉环时，弹性蛋白肽的这种松弛作用会降低或抑制），而乳糖或层粘连蛋白则不能抑制乙酰胆碱诱导的血管舒张。这些发现表明乳糖和层粘连蛋白的抑制作用对弹性蛋白肽受体具有特异性，并且与以前对这些受体的研究一致。由于有证据表明弹性蛋白在几种血管疾病中会降解，因此讨论了弹性蛋白肽可能有助于控制血管紧张度的概念。

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