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Heterogeneity of endothelial cell function for angiotensin conversion in serial-arranged arterioles.

机译:血管紧张素转化的血管内皮细胞功能的异质性。

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The involvement of the endothelial cell in the vasoconstriction induced by angiotensin I and II (AI, AII), and norepinephrine (NE) was studied in microvessels of the hamster cheek pouch before and after the following procedures: endothelial impairment by light-dye treatment, inhibition of angiotensin-converting enzyme (ACE), blockade of endothelium-derived relaxing factor (EDRF) and inhibiting prostaglandin (PG) synthesis. The results showed that in large 2nd-order arterioles, endothelial impairment did not affect the vasoconstrictor activity of AII and NE, nor did it alter ACE activity. However, in small 4th-order arterioles, endothelial impairment significantly reduced angiotensin conversion without altering the vasoconstrictor responses to either AII or NE. Thus, the endothelium plays differential roles in the modulation of local angiotensin conversion in these distinct segments of serial-arranged arterioles. Furthermore, it is unlikely that the vasoconstrictor response to AII in these arterioles ismodulated by the endothelium through a pathway involving the release of EDRF or PGs.
机译:在仓鼠脸颊袋的微血管中,在以下步骤之前和之后研究了内皮细胞参与血管紧张素I和II(AI,AII)和去甲肾上腺素(NE)诱导的血管收缩的作用:通过光染料处理引起的内皮损伤,抑制血管紧张素转换酶(ACE),阻断内皮源性舒张因子(EDRF)和抑制前列腺素(PG)合成。结果表明,在较大的二阶小动脉中,内皮损伤既不影响AII和NE的血管收缩活性,也不改变ACE活性。然而,在小四阶小动脉中,内皮损伤显着降低了血管紧张素转化率,而没有改变对AII或NE的血管收缩反应。因此,在串行排列的小动脉的这些不同部分中,内皮在调节局部血管紧张素转化中起着不同的作用。此外,这些小动脉中对AII的血管收缩反应不太可能被内皮通过涉及EDRF或PGs释放的途径调节。

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