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首页> 外文期刊>Journal of vascular research >Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery.
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Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery.

机译：缺血后后肢灌注，生存和恢复需要Cx40，cx37限制。

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BACKGROUND/AIMS: Ischemia induced by large-vessel obstruction or vascular injury induces a complex cascade of vasodilatory, remodeling and inflammatory pathways; coordination of these processes by vascular endothelium is likely to involve endothelial gap junctions. Vascular endothelium predominantly expresses two connexin (Cx) isoforms: Cx37 and Cx40. The relevance of these Cxs to postischemic limb recovery remains unclear. METHODS: In this study, we use a well-established, severe femoral-saphenous artery-vein pair resection model of unilateral hindlimb ischemia to test the relevance of Cx37 and Cx40 to postischemic tissue survival and recovery of limb perfusion. RESULTS: Cx40-deficient animals (Cx40-/-) experienced a severe reduction in limb perfusion relative to wild-type (WT) animals and exhibited profound and rapid failure of ischemic limb survival. By contrast, the deficit in limb perfusion was less severe in Cx37-ablated (Cx37-/-) animals compared to WT, corresponding with more rapid recovery of limb appearance and use. These results demonstrate that Cx40 is necessary for postischemic limb survival and reperfusion, whereas Cx37 deletion reduces the extent of ischemia in the same model. CONCLUSION: In summary, we present evidence demonstrating that Cx37 and Cx40 uniquely regulate postischemic limb perfusion, altering the severity of ischemic insult and consequent postischemic survival.
机译：背景/目的：由大血管阻塞或血管损伤引起的局部缺血引起血管舒张，重塑和炎症途径的复杂级联。血管内皮对这些过程的协调可能涉及内皮间隙连接。血管内皮主要表达两种连接蛋白（Cx）异构体：Cx37和Cx40。这些Cxs与缺血后肢体恢复的相关性仍不清楚。方法：在这项研究中，我们使用成熟的单侧后肢缺血严重股-大隐动脉-静脉对切除模型，以测试Cx37和Cx40与缺血后组织存活和肢体灌注恢复的相关性。结果：与野生型（WT）动物相比，Cx40缺陷动物（Cx40-/-）的肢体灌注严重减少，并且缺血性肢体存活严重而迅速地失败。相比之下，与WT相比，Cx37消融（Cx37-/-）动物的肢体灌注不足不那么严重，这对应于肢体外观和使用的恢复更快。这些结果表明，Cx40对于缺血后肢体存活和再灌注是必需的，而Cx37缺失减少了同一模型中的缺血程度。结论：总的来说，我们提供的证据表明Cx37和Cx40独特地调节缺血后肢体的灌注，改变了缺血性损伤的严重程度和随后的缺血后存活率。

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