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首页> 外文期刊>Journal of vascular research >Increased Vascular Injury Reduces the Degree of Intimal Hyperplasia following Angioplasty in Rabbits.
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Increased Vascular Injury Reduces the Degree of Intimal Hyperplasia following Angioplasty in Rabbits.

机译：血管损伤的增加减少了兔血管成形术后内膜增生的程度。

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Background/Aims: Formation of intimal hyperplasia following angioplastic procedures can lead to complications, including restenosis and accelerated atherosclerosis. The vessel wall media is a main source of neointimal cells. However, evidence suggests that there are additional cell sources, such as the adventitia. Here we investigate whether an extensive loss of vascular smooth muscle cells (VSMCs) in the media results in less intimal hyperplasia or if there is compensatory cell recruitment from the adventitia. Methods:A balloon catheter was pulled through the rabbit carotid artery 4 times (major injury) or 2 times (minor injury). Adventitial cells were labeled with 5-bromo-2-deoxyuridine or PKH26. Results:The major injury, but not the minor injury, resulted in a complete loss of VSMCs in large parts of the media and significant leukocyte infiltration. The major injury resulted in less neointima compared with the minor injury. The thinnest neointima was seen at the most injured parts of the media in the major injury group. Cell-tracking experiments showed that the media, but not the adventitia, served as a source of neointimal cells. Conclusion: An augmented angioplastic injury with extensive VSMC loss in rabbits reduced the degree of intimal hyperplasia. No compensatory recruitment of neointimal cells from the adventitia occurred.
机译：背景/目的：血管成形手术后内膜增生的形成可能导致并发症，包括再狭窄和动脉粥样硬化加速。血管壁培养基是新内膜细胞的主要来源。但是，证据表明还有其他细胞来源，例如外膜。在这里，我们调查是否在培养基中大量丢失血管平滑肌细胞（VSMC）导致较少的内膜增生，或者是否存在来自外膜的代偿性细胞募集。方法：将气囊导管穿过兔颈动脉4次（严重损伤）或2次（轻微损伤）。生殖细胞用5-溴-2-脱氧尿苷或PKH26标记。结果：主要损伤而非轻度损伤导致大部分培养基中的VSMC完全丧失，并且白细胞明显浸润。与轻伤相比，重伤导致较少的新内膜。在最严重损伤组中，最薄的新内膜见于中层损伤最严重的部位。细胞跟踪实验表明，培养基而不是外膜是新内膜细胞的来源。结论：家兔血管增生损伤严重，血管平滑肌细胞广泛丢失，减少了内膜增生的程度。没有发生来自外膜的新内膜细胞的补偿募集。

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